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Article
Angiotensin II type-2 receptor signaling facilitates liver injury repair and regeneration via inactivation of Hippo pathway
The angiotensin II type 2 receptor (AT2R) is a well-established component of the renin-angiotensin system and is known to counteract classical activation of this system and protect against organ damage. Pharma...
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Article
LncRNA KCNQ1OT1/miR-496/HMGB1 Signaling Axis Promotes Invasion and Migration of Non-small Cell Lung Cancer Cells
Enhanced invasion and migration of non-small cell lung cancer (NSCLC) cells is the major cause of metastasis and poor prognosis in NSCLC. This study was conducted to investigate the role and mechanism of lncRN...
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Article
Berberine improves cognitive impairment by alleviating brain atrophy and promoting white matter reorganization in diabetic db/db mice: a magnetic resonance imaging-based study
Diabetic cognitive impairment is a common complication in type 2 diabetes. Berberine (BBR) is an isoquinoline alkaloid that has been shown to have neuroprotective effects against diabetes. This study aimed to ...
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Article
Open AccessBiological fermentation pilot-scale systems and evaluation for commercial viability towards sustainable biohydrogen production
Featuring high caloric value, clean-burning, and renewability, hydrogen is a fuel believed to be able to change energy structure worldwide. Biohydrogen production technologies effectively utilize waste biomass...
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Article
LncRNA Gm15834 Aggravates Cardiac Hypertrophy by Interacting with Sam68 and Activating NF-κB Mediated Inflammation
Cardiac hypertrophy is the common pathological process of multiple cardiovascular diseases. However, the molecular mechanisms of cardiac hypertrophy are unclear. Long non-coding RNA (lncRNA), a newly discovere...
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Article
Open AccessCirculating metabolomic markers linking diabetic kidney disease and incident cardiovascular disease in type 2 diabetes: analyses from the Hong Kong Diabetes Biobank
The aim of this study was to describe the metabolome in diabetic kidney disease (DKD) and its association with incident CVD in type 2 diabetes, and identify prognostic biomarkers.
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Article
Open AccessPhytoalexin sakuranetin attenuates endocytosis and enhances resistance to rice blast
Phytoalexin sakuranetin functions in resistance against rice blast. However, the mechanisms underlying the effects of sakuranetin remains elusive. Here, we report that rice lines expressing resistance (R) gene...
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Article
Open AccessNeonatal GABAergic transmission primes vestibular gating of output for adult spatial navigation
GABAergic interneurons are poised with the capacity to shape circuit output via inhibitory gating. How early in the development of medial vestibular nucleus (MVN) are GABAergic neurons recruited for feedforwar...
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Article
Automated synthesis of oxygen-producing catalysts from Martian meteorites by a robotic AI chemist
Living on Mars requires the ability to synthesize chemicals that are essential for survival, such as oxygen, from local Martian resources. However, this is a challenging task. Here we demonstrate a robotic art...
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Article
HCLR-Net: Hybrid Contrastive Learning Regularization with Locally Randomized Perturbation for Underwater Image Enhancement
Underwater image enhancement presents a significant challenge due to the complex and diverse underwater environments that result in severe degradation phenomena such as light absorption, scattering, and color ...
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Article
Open AccessHarnessing the potential of HLA-G in cancer therapy: advances, challenges, and prospects
Immune checkpoint blockades have been prized in circumventing and ablating the impediments posed by immunosuppressive receptors, reaching an exciting juncture to be an innovator in anticancer therapy beyond tr...
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Article
Neuronal intranuclear inclusion disease with cortical involvement in left hemisphere: a case report
Neuronal intranuclear inclusion disease (NIID) is a rare highly heterogeneous disease. In this paper, we present a case of NIID featured in cortical involvement in left hemisphere of brain and the imaging chan...
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Chapter and Conference Paper
Experience Design Assisted in Improving the Efficiency of Adolescent Invisible Orthodontic Treatment
Malocclusion is a prevalent oral condition that typically necessitates orthodontic treatment to adjust the arrangement of teeth. Among orthodontic patients, the majority are adolescents, and nowadays, adolesce...
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Article
Toripalimab plus nab-paclitaxel in metastatic or recurrent triple-negative breast cancer: a randomized phase 3 trial
The combination of immune-checkpoint blockade with chemotherapy for the first-line treatment of advanced triple-negative breast cancer (TNBC) has generated mixed results. TORCHLIGHT is a randomized, double-bli...
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Article
Open AccessAdipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM) causes the myocardium to rely on fatty acid β-oxidation for energy. The accumulation of intracellular lipids and fatty acids in the myocardium usually results in lipotoxicity, whi...
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Article
Open AccessCorrection: Saikosaponin D exerts antidepressant effect by regulating Homer1-mGluR5 and mTOR signaling in a rat model of chronic unpredictable mild stress
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Article
Open AccessGenetic diversity of field Fusarium asiaticum and Fusarium graminearum isolates increases the risk of fungicide resistance
Fusarium head blight (FHB) caused by Fusarium species, seriously threatens the safety of wheat (Triticum aestivum) production. Resistant cultivars and fungicides are frequently used to control these FHB pathogens...
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Article
Efficient genome editing in cotton using the virus-mediated CRISPR/Cas9 and grafting system
The extensive application of CRISPR in cotton was limited due to the labor-intensive transformation process. Thus, we here established a convenient method of CRISPR in cotton by CLCrV-mediated sgRNA delivery.
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Article
Open AccessA human lung alveolus-on-a-chip model of acute radiation-induced lung injury
Acute exposure to high-dose gamma radiation due to radiological disasters or cancer radiotherapy can result in radiation-induced lung injury (RILI), characterized by acute pneumonitis and subsequent lung fibro...
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Article
Open AccessSAPT: a synchrotron-based proton therapy facility in Shanghai
Because of its excellent dose distribution, proton therapy is becoming increasingly popular in the medical application of cancer treatment. A synchrotron-based proton therapy facility was designed and construc...
