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  1. Article

    MARK4 controls ischaemic heart failure through microtubule detyrosination

    Myocardial infarction is a major cause of premature death in adults. Compromised cardiac function after myocardial infarction leads to chronic heart failure with systemic health complications and a high mortal...

    **an Yu, **ao Chen, Mamta Amrute-Nayak, Edward Allgeyer, Aite Zhao… in Nature (2021)

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  2. Article

    Open Access

    MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism

    Excessive activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome is involved in many chronic inflammatory diseases, including cardiovascular and Alzheimer’s disease. Here we show that micr...

    Xuan Li, Sarah Thome, **aodan Ma, Mamta Amrute-Nayak… in Nature Communications (2017)

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  3. No Access

    Article

    Single-molecule assays reveal that RNA localization signals regulate dynein–dynactin copy number on individual transcript cargoes

    Bullock and colleagues have reconstituted in vitro the microtubule-driven transport of RNAs to specific localizations in Drosophila melanogaster embryos. They show that a set of localized messenger nucleoproteins...

    Mamta Amrute-Nayak, Simon L. Bullock in Nature Cell Biology (2012)