21 Result(s)
within
Makoto Suzuki
Biomedicine
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Article
Open AccessNovel protective effect of the FOXO3 longevity genotype on mechanisms of cellular aging in Okinawans
The genetic association of FOXO3 genotypes with human longevity is well established, although the mechanism is not fully understood. We now report on the relationship of the FOXO3 longevity variant rs2802292 with...
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Article
Open AccessEfficacy and safety of add-on mirogabalin to conventional therapy for the treatment of peripheral neuropathic pain after thoracic surgery: the multicenter, randomized, open-label ADMIT-NeP study
For chronic pain after thoracic surgery, optimal timing of its diagnosis and effective treatment remains unresolved, although several treatment options are currently available. We examined the efficacy and saf...
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Chapter
Molecular Imaging of PD-1 Unveils Unknown Characteristics of PD-1 Itself by Visualizing “PD-1 Microclusters”
Programmed cell death-1 (PD-1) is one of the most famous coinhibitory receptors that are expressed on effector T cells to regulate their function. The PD-1 ligands, PD-L1 and PD-L2, are expressed by various ce...
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Article
Open AccessA novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression of acute leukemia with rearranged MLL1 or mutated NPM1
Mixed lineage leukemia 1-rearranged (MLL1-r) acute leukemia patients respond poorly to currently available treatments and there is a need to develop more effective therapies directly disrupting the Menin‒MLL1 com...
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Article
Pan-cancer methylome analysis for cancer diagnosis and classification of cancer cell of origin
The accurate and early diagnosis and classification of cancer origin from either tissue or liquid biopsy is crucial for selecting the appropriate treatment and reducing cancer-related mortality. Here, we estab...
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Article
Open AccessA single-arm, phase 2 study of adjuvant chemotherapy with oral tegafur-uracil for pathologically lymphovascular invasion positive stage IA non-small cell lung cancer: LOGIK0602 study
Lymphovascular invasion (LVI), which includes vascular or lymphatic invasions, is a representative prognostic factor even in patients with resected stage IA non-small cell lung cancer (NSCLC). Because tegafur-...
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Article
Open AccessSupport Vector Machine-Based Classifier for the Assessment of Finger Movement of Stroke Patients Undergoing Rehabilitation
Traditionally, clinical evaluation of motor paralysis following stroke has been of value to physicians and therapists because it allows for immediate pathophysiological assessment without the need for speciali...
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Protocol
Erratum to: NanoCAGE: A Method for the Analysis of Coding and Noncoding 5′-Capped Transcriptomes
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Protocol
NanoCAGE: A Method for the Analysis of Coding and Noncoding 5′-Capped Transcriptomes
Transcripts in all eukaryotes are characterized by the 5′-end specific cap structure in mRNAs. Cap Analysis Gene Expression or CAGE makes use of these caps to specifically obtain cDNA fragments from the 5′-end...
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Article
Activating transcription factor 5 (ATF5) is essential for the maturation and survival of mouse basal vomeronasal sensory neurons
Activating transcription factor 5 (ATF5) is a member of the CREB/ATF family of transcription factors, which is highly expressed in olfactory chemosensory tissues, the main olfactory epithelium and vomeronasal ...
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Article
Open AccessInformatics framework of traditional Sino-Japanese medicine (Kampo) unveiled by factor analysis
Kampo, an empirically validated system of traditional Sino-Japanese medicine, aims to treat patients holistically. This is in contrast to modern medicine, which focuses in principle on treating the affected pa...
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Article
Time Course of Change in Movement Structure During Learning of Goal-Directed Movement
Primary and secondary submovements are important in human movements. The purpose of this study was to examine the time course of changes in kinematics and electromyography (EMG) parameters for primary and seco...
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Article
Activation of the Human Premotor Cortex During Motor Preparation in Visuomotor Tasks
Functional brain map** studies in humans suggest that both motor and premotor cortices interact during movement execution. The aim of this study was to investigate whether the premotor cortex also participat...
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Article
Open AccessModulation of the cortical silent period elicited by single- and paired-pulse transcranial magnetic stimulation
The cortical silent period (CSP) elicited by transcranial magnetic stimulation (TMS) is affected by changes in TMS intensity. Some studies have shown that CSP is shortened or prolonged by short-interval intrac...
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Chapter
The Molecular Mechanism of Multifunctional Mechano-Gated Channel TRPV4
Transient receptor potential vanilloid 4 (TRPV4) is a member of the TRP family of channels. It contains 6 transmembrane domains and was first identified as a hypoosmolality-activated Ca2+ permeable channel. TRPV4...
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Article
Open AccessAberrant methylation of N-methyl-D-aspartate receptor type 2B (NMDAR2B) in non-small cell carcinoma
N-methyl-D-aspartate receptors (NMDAR) act as tumor suppressors of digestive malignancies. The expression and genetic methylation patterns of NMDAR2B in non-small cell lung cancer (NSCLC) are unknown.
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Chapter
Okinawa: A Naturally Calorie Restricted Population
The people of Okinawa prefecture (southernmost island chain of Japan) are among the longest lived in the world, in terms of average life expectancy at birth, life expectancy at older ages, centenarian prevalen...
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Article
Open AccessSpontaneous regression of bone metastasis from renal cell carcinoma; A case report
Spontaneous regression of metastatic renal cell carcinoma is rarely observed.
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Article
Large-scale molecular screening for galactosemia alleles in a pan-ethnic population
DNA samples from 4,796 subjects from diverse ethnic groups were screened for five frequently encountered galactose-1-phosphate uridyl transferase (GALT) mutations: S135L (cDNA nt 404C→T, as numbered from the ...
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Article
A new pseudo-peptide of Arg-Gly-Asp (RGD) with inhibitory effect on tumor metastasis and enzymatic degradation of extracellular matrix
A series of pseudo-peptide analogs of the Arg-Gly-Asp (RGD) sequence of fibronectin have been synthe-sized, and their anti-metastatic effects in mice and inhibitory effects on tumor cell invasion in vitro have...
