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  1. No Access

    Article

    The PMAIP1 Gene on Chromosome 18 is a Candidate Tumor Suppressor Gene in Human Pancreatic Cancer

    Frequent loss of heterozygosity on the long arm of chromosome 18 is observed in pancreatic cancer. Previous studies suggested the existence of one or more tumor-suppressor genes other than SMAD4 on chromosome 18....

    Masaharu Ishida, Makoto Sunamura, Toru Furukawa… in Digestive Diseases and Sciences (2008)

  2. No Access

    Article

    Intraductal papillary-mucinous adenocarcinoma in the remnant pancreas after pancreatoduodenectomy for cancer of Vater's papilla associated with intraductal papillary-mucinous adenoma

    A 72-year-old woman, who had undergone pylorus-preserving pancreatoduodenectomy 3 years before for cancer of Vater's papilla associated with a branch-type intraductal papillary-mucinous adenoma (IPMA), develop...

    Masaharu Ishida, Shinichi Egawa… in Journal of Hepato-Biliary-Pancreatic Surge… (2007)

  3. No Access

    Article

    Gene therapy for pancreatic cancer based on genetic characterization of the disease

    In order to develop an effective therapeutic intervention for patients with pancreatic cancer, we analyzed the association of loss of heterozygosity (LOH) with the clinicopathological features of the disease....

    Makoto Sunamura, Toshimasa Yatsuoka… in Journal of Hepato-Biliary-Pancreatic Surge… (2002)

  4. No Access

    Article

    Cytokine modulation in acute pancreatitis

    The clinical manifestations of acute pancreatitis (AP) vary significantly from mild to lethal in form, the severity of the disease being largely determined by the actions of various kinds of inflammatory medi...

    Jun-ichiro Yamauchi, Kazuhiko Shibuya… in Journal of Hepato-Biliary-Pancreatic Surge… (2001)

  5. No Access

    Chapter and Conference Paper

    Cytotoxic Effect of Bone Marrow-Derived Dendritic Cells

    Some reports suggest that cancer patients have a better prognosis when dendritic cells (DCs) infiltrate their tumors. Although the role of these DCs is not fully understood, we focused on a potential effector ...

    Hiromune Shimamura, Fuyuhiko Motoi… in Trends in Gastroenterology and Hepatology (2001)

  6. No Access

    Chapter and Conference Paper

    Controlling Tumor Microenvironment by the Antiangiogenesis Strategy

    Angiogenesis occurs when the balance between negative and positive regulators inclines toward the latter, allowing the tumor and metastases to develop. Studies have found that genetic alterations may correlate...

    Makoto Sunamura, Dan G. Duda, Lucian Lozonschi… in Trends in Gastroenterology and Hepatology (2001)

  7. No Access

    Article

    Preventing effect of anti-ICAM-1 and anti-LFA-1 monoclonal antibodies on murine islet allograft rejection

    Immunosuppressive potentials of the blockade of intercellular adhesion molecule-1 (ICAM)-1/leukocyte function-associated antigen 1 (LFA-1) were examined in a murine islet allotransplantation model by using blo...

    Kosuke Arai, Makoto Sunamura, Yasushi Wada… in International Journal of Pancreatology (1999)

  8. No Access

    Article

    Genomic analysis of the thymine-DNA glycosylase (TDG) gene on 12q22–q24.1 in human pancreatic ductal adenocarcinoma

    Background. Recently, a human G/T-specific TDG gene was identified. This protein acts in a system correcting G/T mispairs to G/C pairs. TDG was mapped to chromosome bands 12q22–q24.1, one of the ...

    Toshimasa Yatsuoka, Toru Furukawa, Tadayoshi Abe… in International Journal of Pancreatology (1999)

  9. No Access

    Article

    Intraoperative radiotherapy for pancreatic adenocarcinoma

    Intraoperative radiotherapy (IORT) is an innovative treatment approach for cancer of the pancreas. The common causes of treatment failure in pancreatic cancer are regional recurrence and distant metastasis. W...

    Makoto Sunamura, Masao Kobari… in Journal of Hepato-Biliary-Pancreatic Surge… (1998)

  10. No Access

    Article

    Pancreatic microcirculation in acute pancreatitis

    We present a review of the microvascular morphology of the pancreas and microstructure of the pancreatic lobule, and report our experimental results of the investigation of pancreatic microcirculation followi...

    Makoto Sunamura, Jun-ichiro Yamauchi… in Journal of Hepato-Biliary-Pancreatic Surge… (1998)

  11. No Access

    Article

    Mucin-producing tumor of the pancreas — surgical treatment

    To evaluate appropriate surgical treatment and to predict prognosis for mucin-producing tumors (MPTs) of the pancreas, we conducted a retrospective clinicopathological study in 25 patients with MPT. Eight pati...

    Hiromune Shimamura, Tohru Furukawa… in Journal of Hepato-Biliary-Pancreatic Surge… (1997)

  12. No Access

    Article

    Strategy for treatment of acute necrotizing pancreatitis: Importance of continuous regional arterial infusion of protease inhibitor and antibiotics in the early phase

    A new strategy for the treatment of acute necrotizing pancreatitis (ANP) is reported. In this prospective study, all patients received intensive medical support. Surgery was performed in patients with infected...

    Kazunori Takeda, Jun-Ichiro Yamauchi… in Journal of Hepato-Biliary-Pancreatic Surge… (1996)

  13. No Access

    Article

    How I do it — Necrosectomy in acute pancreatitis. Open drainage with diverting ileostomy for acute necrotizing pancreatitis

    Infected pancreatic necrosis which spreads extensively in the retroperitoneal space requires open drainage to prevent the formation of residual abscess. With open drainage and repeated debridement, we often en...

    Seiki Matsuno, Kazunori Takeda… in Journal of Hepato-Biliary-Pancreatic Surge… (1994)

  14. No Access

    Article

    5th Japanese Association of Hepato-Biliary-Pancreatic Surgery

    Kohji Miyazaki, Nobuo Tsutsumi… in Journal of Hepato-Biliary-Pancreatic Surge… (1993)