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within Maik Kschischo Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter

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  1. Article

    Open Access

    Systems approaches identify the consequences of monosomy in somatic human cells

    Chromosome loss that results in monosomy is detrimental to viability, yet it is frequently observed in cancers. How cancers survive with monosomy is unknown. Using p53-deficient monosomic cell lines, we find t...

    Narendra Kumar Chunduri, Paul Menges, **aoxiao Zhang… in Nature Communications (2021)

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  2. Article

    Open Access

    Learning (from) the errors of a systems biology model

    Mathematical modelling is a labour intensive process involving several iterations of testing on real data and manual model modifications. In biology, the domain knowledge guiding model development is in many c...

    Benjamin Engelhardt, Holger Frőhlich, Maik Kschischo in Scientific Reports (2016)

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  3. Article

    Correction: Corrigendum: Replication stress links structural and numerical cancer chromosomal instability

    Nature 494, 492–496 (2013); doi:10.1038/nature11935 In this Letter we inadvertently omitted full details of The Cancer Genome Atlas data sets. The Acknowledgements should have included these sentences: “The re...

    Rebecca A. Burrell, Sarah E. McClelland, David Endesfelder, Petra Groth… in Nature (2013)

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  4. No Access

    Article

    Replication stress links structural and numerical cancer chromosomal instability

    A mechanism to explain chromosomal instability (CIN) in colorectal cancer is demonstrated; three new CIN-suppressor genes (PIGN, MEX3C and ZNF516) encoded on chromosome 18q are identified, the loss of which leads...

    Rebecca A. Burrell, Sarah E. McClelland, David Endesfelder, Petra Groth… in Nature (2013)