-
Article
Genetics of myocardial interstitial fibrosis in the human heart and association with disease
Myocardial interstitial fibrosis is associated with cardiovascular disease and adverse prognosis. Here, to investigate the biological pathways that underlie fibrosis in the human heart, we developed a machine ...
-
Article
Genetic analysis of right heart structure and function in 40,000 people
Congenital heart diseases often involve maldevelopment of the evolutionarily recent right heart chamber. To gain insight into right heart structure and function, we fine-tuned deep learning models to recognize...
-
Article
Deep learning enables genetic analysis of the human thoracic aorta
Enlargement or aneurysm of the aorta predisposes to dissection, an important cause of sudden death. We trained a deep learning model to evaluate the dimensions of the ascending and descending thoracic aorta in...