10 Result(s)
within
MARIA PELLEGRINI
Life Sciences
English
Animal Anatomy / Morphology / Histology
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Chapter
Secondary and tertiary fold of the human parathyroid hormone1–34 in different environments as a pathway to bioactive conformation
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Chapter
Lactam cyclization [i to (i+4)] for nucleation/stabilization of α-helices?
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Chapter
RS-66271, a clinical candidate derived from parathyroid hormone related protein: The role of enhanced amphiphilic helicity
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Chapter
CtrΔe13, a Calcitonin Receptor Isoform Lacking 14 Amino Acids in Transmembrane Helix 7: Structure and Topology
The peptide hormone calcitonin (CT) acts through its G-protein coupled receptor to reduce serum calcium levels by inhibiting bone resorption and promoting renal calcium excretion. In addition, CT modulates the...
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Chapter
Probing the Importance of the N-Terminal Helix of Parathyroid Hormone: Introduction of Cyclohexylalanine to Tether to the Membrane
We have previously described the structural features of parathyroid hormone (PTH) as determined by high-resolution NMR under a number of different conditions, including the membrane mimetic environment of dode...
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Chapter
Characterizing the Interactions Between Cholecystokinin and the G-Protein Coupled Receptors CCK1 and CCK2: An NMR-Based Study
Cholecystokinin (CCK) is a peptide hormone and neurotransmitter involved in a number of physiological processes of the gall bladder and pancreas, in the gastrointestinal tract, and anxiety, memory, and analges...
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Article
Conformational investigation of a novel dipeptide based molecular scaffold
The conformational features of a novel, dipeptide-based molecular scaffold are described. Four model systems of a trisubstituted 1,4-diazepine-3-one system, varying in the chirality and amino acid within the r...
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Article
1,2,5-Trisubstituted 1,4-diazepine-3-one: A novel dipeptidomimetic molecular scaffold
The continuing effort to transform bioactive peptides into non-peptide peptidomimetics of therapeutic potential requires a diversity of tools such as molecular scaffolds, pseudopeptide modifications, and confo...
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Article
1,2,5-Trisubstituted 1,4-diazepine-3-one: A novel dipeptidomimetic molecular scaffold
The continuing effort to transform bioactive peptides into non-peptide peptidomimetics of therapeutic potential requires a diversity of tools such as molecular scaffolds, pseudopeptide modifications, and confo...
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Article
Conformational investigation of a novel, dipeptide based molecular scaffold
The conformational features of a novel, dipeptide-based molecular scaffold are described. Four model systems of a trisubstituted 1,4-diazepine-3-one system, varying in the chirality and amino acid within the r...
