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  1. Article

    Open Access

    Glutathione peroxidase 1 deficiency attenuates concanavalin A-induced hepatic injury by modulation of T-cell activation

    Concanavalin A (Con A)-induced hepatitis model is well-established experimental T cell-mediated liver disease. Reactive oxygen species (ROS) is associated with T-cell activation and proliferation, but continue...

    D H Lee, D J Son, M H Park, D Y Yoon, S B Han, J T Hong in Cell Death & Disease (2016)

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    Article

    eIF5A isoforms and cancer: two brothers for two functions?

    Eukaryotic translation initiation factor 5A (eIF5A) is the only cellular protein that contains the unusual amino acid hypusine [N ε-(4-amino-2-hydroxybutyl)lysine]. The role of hypusine formation ...

    M. Caraglia, M. H. Park, E. C. Wolff, M. Marra, A. Abbruzzese in Amino Acids (2013)

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    Article

    Functional significance of eIF5A and its hypusine modification in eukaryotes

    The unusual basic amino acid, hypusine [Nε-(4-amino-2-hydroxybutyl)-lysine], is a modified lysine with the addition of the 4-aminobutyl moiety from the polyamine spermidine. This naturally occurring amino acid is...

    M. H. Park, K. Nishimura, C. F. Zanelli, S. R. Valentini in Amino Acids (2010)

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    Article

    Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification

    A naturally occurring unusual amino acid, hypusine [N ɛ-(4-amino-2-hydroxybutyl)-lysine] is a component of a single cellular protein, eukaryotic translation initiation factor 5A (eIF5A). It is a m...

    E. C. Wolff, K. R. Kang, Y. S. Kim, M. H. Park in Amino Acids (2007)

  5. No Access

    Chapter

    Deoxyhypusine Hydroxylase

    The unusual basic amino acid hypusine [Nε-(4-amino-2-hydroxybutyl) lysine] is a derivative of lysine which was originally isolated from a trichloroacetic acid-soluble extract of bovine brain (1). Subsequently it ...

    A. Abbruzzese, V. Liguori, M. H. Park in Progress in Polyamine Research (1988)

  6. No Access

    Chapter

    Biosynthesis of Hypusine in eIF-4D Precursors

    An unusual basic amino acid hypusine was discovered in 1971 in extracts of bovine brain by Shiba and coworkers, who determined its chemical structure as Nε -(4-amino-2-hydroxybutyl)lysine(1). Its distribution in ...

    M. H. Park, E. C. Wolff, A. Abbruzzese, J. E. Folk in Progress in Polyamine Research (1988)