17 Result(s)
within
M. von Lilienfeld-Toal
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Article
Open AccessCOVID-19 in cancer patients: clinical characteristics and outcome—an analysis of the LEOSS registry
Since the early SARS-CoV-2 pandemic, cancer patients have been assumed to be at higher risk for severe COVID-19. Here, we present an analysis of cancer patients from the LEOSS (Lean European Open Survey on SAR...
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Das Deutsche Pilz-Keratitis-Register
Die Pilzkeratitis ist ein ernst zu nehmendes, relativ seltenes Krankheitsbild, zu dem es bis zur Gründung des Deutschen Pilz-Keratitis-Registers 2015 keine gezielte Datenerfassung in Deutschland gab.
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Open AccessManagement of sepsis in neutropenic cancer patients: 2018 guidelines from the Infectious Diseases Working Party (AGIHO) and Intensive Care Working Party (iCHOP) of the German Society of Hematology and Medical Oncology (DGHO)
Sepsis and septic shock are major causes of mortality during chemotherapy-induced neutropenia for malignancies requiring urgent treatment. Thus, awareness of the presenting characteristics and prompt managemen...
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Article
Pneumonien bei immunsupprimierten Patienten
Immunsupprimierte Patienten erkranken häufiger und schwerer an Pneumonien als immunkompetente Personen. Sie zeigen ein breites Erregerspektrum, wobei beteiligte Erreger direkt mit der Art der Immunsuppression ...
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Open AccessDiagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)
Fever may be the only clinical symptom at the onset of infection in neutropenic cancer patients undergoing myelosuppressive chemotherapy. A prompt and evidence-based diagnostic and therapeutic approach is mand...
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Open AccessInfluenza virus infections in patients with malignancies –– characteristics and outcome of the season 2014/15. A survey conducted by the Infectious Diseases Working Party (AGIHO) of the German Society of Haematology and Medical Oncology (DGHO)
Influenza virus infections (IVI) may pose a vital threat to immunocompromised patients such as those suffering from malignancies, but specific data on epidemiology and outcome in these patients are scarce. In ...
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Outcome of empirical or targeted antifungal therapy after antifungal prophylaxis in febrile neutropenia
Azole prophylaxis has been shown to be effective in preventing invasive fungal infections (IFIs) and increasing survival in patients with prolonged neutropenia after myelosuppressive chemotherapy for haematolo...
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Polymorphisms of Toll-like receptors (TLR2 and TLR4) are associated with the risk of infectious complications in acute myeloid leukemia
Infectious complications continue to be one of the major causes of morbidity and mortality in patients with acute myeloid leukemia (AML). Several single-nucleotide polymorphisms (SNPs) of Toll-like receptors (...
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Tigecycline in febrile neutropenic patients with haematological malignancies: a retrospective case documentation in four university hospitals
Tigecycline (TGC) is a first-in-class glycylcycline with an expanded spectrum of activity. Although TGC has not been prospectively studied in febrile neutropenia (FN), we observed that occasionally critically...
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Successful management of Candida krusei monoarthritis after allo-SCT
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Open AccessPrimary prophylaxis of bacterial infections and Pneumocystis jirovecii pneumonia in patients with hematological malignancies and solid tumors
Bacterial infections are the most common cause for treatment-related mortality in patients with neutropenia after chemotherapy. Here, we discuss the use of antibacterial prophylaxis against bacteria and Pneumocys...
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Plerixafor with and without chemotherapy in poor mobilizers: results from the German compassionate use program
The CXCR4-inhibitor plerixafor mobilizes hematopoietic stem cells amplifying the effects of granulocyte-CSF (G-CSF). Before approval plerixafor was used in a compassionate use program (CUP) for patients who fa...
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An Audit of Efficacy and Toxicity of Teicoplanin Versus Vancomycin in Febrile Neutropenia: Is the Different Toxicity Profile Clinically Relevant?
Glycopeptides are often used for persistent fever in neutropenic patients. This study compares efficacy and toxicity of teicoplanin and vancomycin.
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Prevention of thalidomide- and lenalidomide-associated thrombosis in myeloma
The incidence of venous thromboembolism (VTE) is more than 1‰ annually in the general population and increases further in cancer patients. The risk of VTE is higher in multiple myeloma (MM) patients who receiv...
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Change of procalcitonin predicts clinical outcome of febrile episodes in patients with hematological malignancies
Procalcitonin (PCT) was widely investigated in febrile neutropenia as an indirect marker of infection. Many institutions also use PCT as a tool to monitor the course of a febrile episode because increases in P...
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Open AccessIsolated γδ T cells express natural cytotoxicity receptors
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Markers of bacteremia in febrile neutropenic patients with hematological malignancies: procalcitonin and IL-6 are more reliable than C-reactive protein
Since neutropenic patients with hematological malignancies are at high risk of contracting life-threatening infections, specific markers of infection are needed in cases of febrile neutropenia. The study prese...
