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Article
Money back guarantee? A cost–benefit framework of performance-based agreements (PBAs) for the reimbursement of pharmaceuticals
The aim of this paper is to provide an empirical framework based on a discrete-time Markov chain to assess the costs and benefits of Performance Based Agreements (PBAs) for the reimbursement of pharmaceuticals...
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Article
Economic evaluation of Zepatier for the management of HCV in the Italian scenario
Hepatitis C virus (HCV) is a major health issue worldwide. New generation of direct-active antiviral medications is an epoch-making turning point in the management of HCV infections.
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Article
Cost-Effectiveness Analysis of Lesinurad/Allopurinol Versus Febuxostat for the Management of Gout/Hyperuricemia in Italy
Until very recently the only therapeutic alternative for the management of patients affected by gout/hyperuricemia that did not respond to a first-line treatment based on allopurinol alone or who cannot tolera...
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Article
A clinical-molecular prognostic model to predict survival in patients with post polycythemia vera and post essential thrombocythemia myelofibrosis
Polycythemia vera (PV) and essential thrombocythemia (ET) are myeloproliferative neoplasms with variable risk of evolution into post-PV and post-ET myelofibrosis, from now on referred to as secondary myelofibr...
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Article
Economic Analysis and Budget Impact of Tenofovir and Entecavir in the First-Line Treatment of Hepatitis B Virus in Italy
Chronic hepatitis B is a common, progressive disease, particularly when viral replication is detected. Oral antivirals can suppress viral replication and prevent or delay the development of cirrhosis and liver...
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Article
Driver mutations’ effect in secondary myelofibrosis: an international multicenter study based on 781 patients
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Article
Open AccessTranscriptomic analyses and leukocyte telomere length measurement in subjects exposed to severe recent stressful life events
Stressful life events occurring in adulthood have been found able to affect mood and behavior, thus increasing the vulnerability for several stress-related psychiatric disorders. However, although there is ple...
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Article
Open AccessSplanchnic vein thrombosis in myeloproliferative neoplasms: risk factors for recurrences in a cohort of 181 patients
We retrospectively studied 181 patients with polycythaemia vera (n=67), essential thrombocythaemia (n=67) or primary myelofibrosis (n=47), who presented a first episode of splanchnic vein thrombosis (SVT). Budd–C...
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Article
High rate of recurrent venous thromboembolism in patients with myeloproliferative neoplasms and effect of prophylaxis with vitamin K antagonists
The optimal duration of treatment with vitamin K antagonists (VKA) after venous thromboembolism (VTE) in patients with Philadelphia-negative myeloproliferative neoplasms (MPNs) is uncertain. To tackle this iss...
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Article
Open AccessPractice-relevant revision of IPSET-thrombosis based on 1019 patients with WHO-defined essential thrombocythemia
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Article
The cost effectiveness of Botox in Italian patients with chronic migraine
Migraine is a primary headache which World Health Organization ranks in 19th place in the list of disabling diseases. In Europe, in 2004, the total costs for migraine were quantified by Stovner and Berg, Eur J...
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Article
Common variant at 16p11.2 conferring risk of psychosis
Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as m...
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Article
Valutazione economica e analisi di budget impact di S-1 (tegafur/gimeracil/oteracil) in pazienti con carcinoma gastrico avanzato
The aim of this study was to assess whether S-1 might represent a valuable therapeutic option for patients with advanced gastric cancer in comparison to other available therapies (5-FU, capecitabine), consider...
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Article
Open AccessSurvival and prognosis among 1545 patients with contemporary polycythemia vera: an international study
Under the auspices of an International Working Group, seven centers submitted diagnostic and follow-up information on 1545 patients with World Health Organization-defined polycythemia vera (PV). At diagnosis, ...
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Article
Valutazione economica della tossina botulinica per la profilassi dell’emicrania cronica
To evaluate the cost-effectiveness of onabotulinumtoxinA versus placebo in patients with chronic migraine from the Italian National Health Service and a societal perspective.
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Article
Valutazione economica dei programmi di screening contro il cancro del colon retto: evidenze indirette di lungo periodo e sostenibilità finanziaria in un’ottica di programmazione regionale
About 37,733 new cases of colorectal cancer (CRC) are yearly diagnosed in Italy. Abruzzo regional estimates for 2008 report 902 new cases, 378 deaths and 4,686 prevalent cases. Twenty percent of patients are n...
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Article
Incidence and risk factors for bleeding in 1104 patients with essential thrombocythemia or prefibrotic myelofibrosis diagnosed according to the 2008 WHO criteria
In an international study of 1104 patients with essential thrombocythemia (ET), a histological review according to the 2008 World Health Organization (WHO) criteria confirmed ET in 891 patients (WHO-ET, 81%), ...
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Article
Expanding the range of ZNF804A variants conferring risk of psychosis
A trio of genome-wide association studies recently reported sequence variants at three loci to be significantly associated with schizophrenia. No sequence polymorphism had been unequivocally (P<5 × 10−8) associat...
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Article
Copy number variations of chromosome 16p13.1 region associated with schizophrenia
Deletions and reciprocal duplications of the chromosome 16p13.1 region have recently been reported in several cases of autism and mental retardation (MR). As genomic copy number variants found in these two dis...
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Article
La porpora trombocitopenica idiopatica: una stima del costo della malattia in Italia
Immune thrombocytopenic purpura (ITP), a rare autoimmune disorder characterized by formation of anti-platelet antibodies, causes an increased medical resource utilization associated with bleeding events, hospi...
