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Open AccessHybrid Modelling of Transarterial Chemoembolisation Therapies (TACE) for Hepatocellular Carcinoma (HCC)
We extend an agent-based multiscale model of vascular tumour growth and angiogenesis to describe transarterial chemoembolisation (TACE) therapies. The model accounts for tumour and normal cells that are both n...
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Article
Open AccessCorrelative microscopy approach for biology using X-ray holography, X-ray scanning diffraction and STED microscopy
We present a correlative microscopy approach for biology based on holographic X-ray imaging, X-ray scanning diffraction, and stimulated emission depletion (STED) microscopy. All modalities are combined into th...
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Chapter
3D Multiscale Modelling of Angiogenesis and Vascular Tumour Growth
We present a three-dimensional, multiscale model of vascular tumour growth, which couples nutrient/growth factor transport, blood flow, angiogenesis, vascular remodelling, movement of and interactions between ...
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Article
Quantitative analysis of isoprenoid diphosphate intermediates in recombinant and wild-type Escherichia coli strains
In biotechnology, the heterologous biosynthesis of isoprenoid compounds in Escherichia coli is a field of great interest and growth. In order to achieve higher isoprenoid yields in heterologous E. coli strains, i...
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Article
Identification of factors impeding the production of a single-chain antibody fragment in Escherichia coli by comparing in vivo and in vitro expression
The atrazine-specific single-chain variable antibody fragments (scFv) K411B was produced by expression in either the cytoplasm or the periplasm of Escherichia coli BL21(DE3). For periplasmic production, the pelB ...
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Book
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Article
Production of sophorolipids from whey
Sophorolipids, obtained by a two-stage process starting from deproteinized whey concentrate using Cryptococcus curvatus ATCC 20509 and Candida bombicola ATCC 22214, were compared to products from one-stage proce...
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Article
Application of different polarimetric methods for the analysis of enzyme-catalyzed enantioselective reactions
Identification of model parameters in kinetic equations requires the determination of reactant concentrations in the course of time. In the case of enzyme catalyzed enantioselective reactions, three different...
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Article
Production of sophorolipids from whey: development of a two-stage process with Cryptococcus curvatus ATCC 20509 and Candida bombicola ATCC 22214 using deproteinized whey concentrates as substrates
In order to produce sophorolipids from whey, thereby lowering the lactose content and biological oxygen demand, a two-step batch cultivation process was developed including medium sterilization by filtration....
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Article
Growth analysis of a mixed culture during the degradation of 4-aminobenzenesulfonic acid
Growth of a mixed culture, Pseudomonas palleronii and Agrobacterium radiobacter using the toxic chemical “4-aminobenzenesulfonic acid” was followed by: the measurement of the total cell density by using cell coun...
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Chapter
Reaktionstechnische Untersuchungen zur konjugativen Übertragung des TOL-Plasmids pWWO in Suspension und im Biofilm
In industriellen Kläranlagen wird die Abbauleistung gegenüber Fremdstoffen entscheidend durch das stoffwechselphysiologische Potential der vorhandenen Bakterienpopulation bestimmt. Der hohe Anteil verschiedene...
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Chapter and Conference Paper
Biological Treatment of TNT-Contaminated Soil by a Two-Stage Anaerobic/Aerobic Process
TNT is found as a major soil contaminant at the sites of armament plants from World War I and II. While no complete biological mineralization of TNT has yet been found, many bacteria can co-metabolically reduc...
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Chapter
Structured Modelling of Bioreactors
The aim of this contribution is to discuss some new aspects in the design of structured models for stirred tank bioreactors. The modelling strategy starts from a simple multiphase compartment model, which is b...
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Chapter
Bioreactor Coupled On-Line Measurements
Although research on the development of on-line HPLC systems has been conducted for many years, there is still no satisfactory solution available in the area of fully automatic sampling and sample preparation ...
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Article
Potential of Thiobacillus ferrooxidans for waste gas purification. Part 2. Increase in continuous ferrous iron oxidation kinetics using immobilized cells
Thiobacillus ferrooxidans could be used to regenerate ferrous sulphate solution produced in a process to remove H2S from waste gas if the reaction rate could be increased. The aim of the present study was to inc...
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Article
Potential of Thiobacillus ferrooxidans for waste gas purification. Part 1. Kinetics of continuous ferrous iron oxidation
Kinetic data of ferrous iron oxidation by Thionacillus ferrooxidans were determined. The aim was to remove H2S (<0.5 ppm) from waste gas by a process proposed earlier. Kinetic data necessary for industrial scale-...
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Chapter
Bioreactors
The paper is aimed at discussing problems of design and/or choice of appropriate bioreactors for different bioprocesses. Starting from a picture book showing different types of bioreactors an attempt is carrie...
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Chapter
Structured Modelling of Bioreactor Systems
There are two aspects to the discussion of structure in bioreactor modelling. The first aspect concerns the complex interaction of the substructural elements of the cell including the mathematical formulation ...
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Chapter
Gas Analysis and Membrane Probes
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Chapter and Conference Paper
The Performance Measuring Data of a DHW and Stable Heating System
A lot of farms in germany have a high demand of heat at low temperatures (30° C — 50° C) for heating stables, feeding calves or domestic hot water, which could be provided by solar assisted heating systems. Tw...
