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  1. No Access

    Article

    Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases

    The purpose of this study was the appraisal of the clinical and functional consequences of germline mutations within the gene for the IL-2 inducible T-cell kinase, ITK. Among patients with Epstein-Barr virus-d...

    R M Linka, S L Risse, K Bienemann, M Werner, Y Linka, F Krux, C Synaeve… in Leukemia (2012)

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    Article

    The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program

    Microtubule-interfering cancer drugs such as paclitaxel (PTX) often cause chemoresistance and severe side effects, including neurotoxicity. To explore potentially novel antineoplastic molecular targets, we inv...

    S Schmidt, L Schneider, F Essmann, I C Cirstea, F Kuck, A Kletke, R U Jänicke… in Oncogene (2010)

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    Article

    GTPase activating proteins: structural and functional insights 18 years after discovery

    The conversion of guanosine triphosphate (GTP) to guanosine diphosphate (GDP) and inorganic phosphate (Pi) by guanine nucleotide binding proteins (GNBPs) is a fundamental process in living cells and represents an...

    K. Scheffzek, M. R. Ahmadian in Cellular and Molecular Life Sciences CMLS (2005)

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    Article

    Structural and mechanistic insights into the interaction between Rho and mammalian Dia

    Formins are involved in a variety of cellular processes that require the remodelling of the cytoskeleton. They contain formin homology domains FH1 and FH2, which initiate actin assembly1,2. The Diaphanous-related...

    R. Rose, M. Weyand, M. Lammers, T. Ishizaki, M. R. Ahmadian, A. Wittinghofer in Nature (2005)

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    Article

    Characterization of a Paracoccus denitrificans mutant pleiotropically impaired in nitrogen metabolism

    A Tn5 insertional prototrophic mutant of Paracoccus denitrificans (UBM219) was generated which grew on high (>1 mM) but not low (<0.5 mM) ammonium as sole nitrogen source. It did not utilize nitrate and most amin...

    M. R. Ahmadian, H. A. Ghozlan, S. Sabry, D. Kleiner in Archives of Microbiology (1993)