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  1. No Access

    Article

    Inhibition of metastasis by HEXIM1 through effects on cell invasion and angiogenesis

    We report on the role of hexamethylene-bis-acetamide-inducible protein 1 (HEXIM1) as an inhibitor of metastasis. HEXIM1 expression is decreased in human metastatic breast cancers when compared with matched pri...

    W Ketchart, K M Smith, T Krupka, B M Wittmann, Y Hu, P A Rayman, Y Q Doughman… in Oncogene (2013)

  2. No Access

    Article

    The exonuclease activity of hPMC2 is required for transcriptional regulation of the QR gene and repair of estrogen-induced abasic sites

    We have previously reported that the expression of antioxidative stress enzymes is upregulated by trans-hydroxytamoxifen (TOT) in breast epithelial cell lines providing protection against estrogen-induced DNA dam...

    N Krishnamurthy, C R Ngam, A J Berdis, M M Montano in Oncogene (2011)

  3. No Access

    Article

    HEXIM1 is a critical determinant of the response to tamoxifen

    Tamoxifen resistance is a major problem in the treatment of estrogen receptor (ER)-positive patients. We have previously reported that hexamethylene bis-acetamide-inducible protein 1 (HEXIM1) inhibits ERα acti...

    W Ketchart, N Ogba, A Kresak, J M Albert, J J Pink, M M Montano in Oncogene (2011)

  4. No Access

    Article

    HEXIM1 modulates vascular endothelial growth factor expression and function in breast epithelial cells and mammary gland

    Recently, we found that mutation of the C-terminus of transcription factor hexamethylene bisacetamide-inducible protein 1 (HEXIM1) in mice leads to abnormalities in cardiovascular development because of aberra...

    N Ogba, Y Q Doughman, L J Chaplin, Y Hu, M Gargesha, M Watanabe, M M Montano in Oncogene (2010)

  5. No Access

    Article

    hPMC2 is required for recruiting an ERβ coactivator complex to mediate transcriptional upregulation of NQO1 and protection against oxidative DNA damage by tamoxifen

    In the presence of ERβ, trans-hydroxytamoxifen (TOT) protects cells against 17β-estradiol (E2)-induced oxidative DNA damage (ODD) and this correlates with increased expression of the antioxidative enzyme quinone ...

    S P Sripathy, L J Chaplin, N W Gaikwad, E G Rogan, M M Montano in Oncogene (2008)

  6. No Access

    Article

    Protective roles of quinone reductase and tamoxifen against estrogen-induced mammary tumorigenesis

    We previously reported that antiestrogen-liganded estrogen receptor β (ERβ) transcriptionally activates the major detoxifying enzyme quinone reductase (QR) (NAD(P)H:quinone oxidoreductase). Further studies on the...

    M M Montano, L J Chaplin, H Deng, S Mesia-Vela, N Gaikwad, M Zahid, E Rogan in Oncogene (2007)

  7. No Access

    Chapter and Conference Paper

    Estrogen-Receptor and Antiestrogen-Receptor Complexes: Cell- and Promoter-Specific Effects and Interactions with Second Messenger Signaling Pathways

    Estrogens regulate the differentiation, growth, and functioning of many reproductive tissues. They also exert important actions on other tissues, including bone, liver, and the cardiovascular system. Most of t...

    B. S. Katzenellenbogen, M. M. Montano… in Organ-Selective Actions of Steroid Hormones (1995)