28 Result(s)
within
M. Kawahara
English
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Article
Totally laparoscopic resection of right-sided colon cancer using transvaginal specimen extraction with a 10-mm-long abdominal incision
Natural orifice specimen extraction (NOSE) has been developed as a means of decreasing the incidence of surgical wound complications. We refined the procedure for totally laparoscopic colectomy with transvagin...
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Article
A novel LSD1 inhibitor NCD38 ameliorates MDS-related leukemia with complex karyotype by attenuating leukemia programs via activating super-enhancers
Lysine-specific demethylase 1 (LSD1) regulates gene expression by affecting histone modifications and is a promising target for acute myeloid leukemia (AML) with specific genetic abnormalities. Novel LSD1 inhi...
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Article
Open AccessChemotherapy-induced neutropenia as a prognostic factor in advanced non-small-cell lung cancer: results from Japan Multinational Trial Organization LC00-03
Neutropenia is a common adverse reaction of chemotherapy. We assessed whether chemotherapy-induced neutropenia could be a predictor of survival for patients with non-small-cell lung cancer (NSCLC).
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Article
Life cycle of the jellyfish Lychnorhiza lucerna (Scyphozoa: Rhizostomeae)
The life cycle of Lychnorhiza lucerna (Scyphozoa: Rhizostomeae) and the settlement preferences of its larvae were studied using laboratory-based rearing experiments. Mature medusae of L. lucerna were collected fr...
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Chapter and Conference Paper
Paternal Dual Barrier by Ifg2-H19 and Dlk1-Gtl2 to Parthenogenesis in Mice
The functional difference between the maternal and paternal genome, which is characterized by epigenetic modifications during gametogenesis, that is genomic imprinting, prevents mammalian embryos from partheno...
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Article
Open AccessRandomised phase II study of docetaxel/cisplatin vs docetaxel/irinotecan in advanced non-small-cell lung cancer: a West Japan Thoracic Oncology Group Study (WJTOG9803)
Docetaxel plus cisplatin and docetaxel plus irinotecan are active and well-tolerated chemotherapy regimens for advanced non-small-cell lung cancer (NSCLC). A randomised phase II study compared their efficacy a...
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Article
Promotion of corneal epithelial wound healing in diabetic rats by the combination of a substance P-derived peptide (FGLM-NH2) and insulin-like growth factor-1
The healing of corneal epithelial wounds is often delayed in individuals with diabetes. The effect of the combination of a substance P-derived tetrapeptide (phenylalanine-glycine-leucine-methionine amide, or F...
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Article
Effect of low-level laser irradiation on osteoglycin gene expression in osteoblasts
Many studies have attempted to elucidate the mechanism of the biostimulatory effects of low-level laser irradiation (LLLI), but the molecular basis of these effects remains obscure. We investigated the stimula...
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Article
Evaluation of the diagnostic accuracy of the stop codon (SC) assay for identifying protein-truncating mutations in the BRCA1 and BRCA2 genes in familial breast cancer
Screening for protein-truncating mutations of the BRCA1 and BRCA2 genes is useful in genetic testing for familial breast cancer because, first, the methods are usually simple and not expensive, and second, the d...
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Article
Open AccessGemcitabine and vinorelbine followed by docetaxel in patients with advanced non-small-cell lung cancer: a multi-institutional phase II trial of nonplatinum sequential triplet combination chemotherapy (JMTO LC00-02)
To evaluate the efficacy and toxicity of the sequential nonplatinum combination chemotherapy consisting of gemcitabine (GEM) and vinorelbine (VNR) followed by docetaxel (DOC) in patients with advanced non-smal...
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Article
Rapid preparation of indium tin oxide sputtering targets by spark plasma sintering
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Chapter
Structural essentials for novel inhibition of serine protease chymotrypsin
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Article
Early phase II study of S-1, a new oral fluoropyrimidine, for advanced non-small-cell lung cancer
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Article
Open AccessPhase II study of S-1, a novel oral fluorouracil, in advanced non-small-cell lung cancer
The purpose of this study was to evaluate the efficacy and safety of a novel oral anticancer fluoropyrimidine derivative, S-1, in patients receiving initial chemotherapy for unresectable, advanced non-small-ce...
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Article
Open AccessImmunohistochemical analysis of Bcl-2 protein in early squamous cell carcinoma of the bronchus treated with photodynamic therapy
Photodynamic therapy (PDT) in early squamous cell carcinoma of the bronchus has been shown to result in complete response (CR) and cure. However, local recurrence after PDT develops frequently even after compl...
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Article
Methicillin-resistant Staphylococcus aureus enteritis in an immunologically uncompromised infant
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Article
Histological Examination of Bronchial Mucosa after Photodynamic Therapy Showing no Selectivity of Effect between Tumour and Normal Mucosa
.After the treatment for early stage bronchogenic carcinoma including carcinoma in situ with photodynamic therapy (PDT), the degree of bronchial mucosal damage was studied histologically. The influence of trea...
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Article
Second primary tumours in more than 2-year disease-free survivors of small-cell lung cancer in Japan: the role of smoking cessation
Patients with small-cell lung cancer who survive more than 2 years have a significantly increased risk (relative risk of 3.6) of develo** a second primary tumour. The cessation of cigarette smoking after suc...
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Article
Phase II trial of carboplatin plus oral etoposide for elderly patients with small-cell lung cancer
A phase II trial was conducted to evaluate the efficacy and toxicity of the Egorin's carboplatin dosing formula with 14-day oral etoposide in 38 elderly patients with small-cell lung cancer (SCLC). The overall...
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Article
A pilot study of concurrent whole-brain radiotherapy and chemotherapy combined with cisplatin, vindesine and mitomycin in non-small-cell lung cancer with brain metastasis
We have evaluated the feasibility, toxicity, and tumour response of concurrent whole-brain radiotherapy (WBRT) and chemotherapy with cisplatin, vindesine and mitomycin in the treatment of 33 patients with brai...
