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Open AccessMathematical modelling of contact dermatitis from nickel and chromium
Dermal exposure to metal allergens can lead to irritant and allergic contact dermatitis (ACD). In this paper we present a mathematical model of the absorption of metal ions, hexavalent chromium and nickel, int...
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Article
Open AccessA high-density immunoblotting methodology for quantification of total protein levels and phosphorylation modifications
The components of many signaling pathways have been identified and there is now a need to conduct quantitative data-rich temporal experiments for systems biology and modeling approaches to better understand pa...
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Article
Overview of Mathematical Approaches Used to Model Bacterial Chemotaxis II: Bacterial Populations
We review the application of mathematical modeling to understanding the behavior of populations of chemotactic bacteria. The application of continuum mathematical models, in particular generalized Keller–Segel...
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Article
Overview of Mathematical Approaches Used to Model Bacterial Chemotaxis I: The Single Cell
Mathematical modeling of bacterial chemotaxis systems has been influential and insightful in hel** to understand experimental observations. We provide here a comprehensive overview of the range of mathematic...
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Article
Modelling the Cell Cycle and Cell Movement in Multicellular Tumour Spheroids
This paper analyses a recent mathematical model of avascular tumour spheroid growth which accounts for both cell cycle dynamics and chemotactic driven cell movement. The model considers cells to exist in one o...
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Article
Modelling Cell Growth and its Modulation of the G1/S Transition
We present a model for the regulation of the G1/S transition by cell growth in budding yeast. The model includes a description of cell size, the extracellular nutrient concentration and a simplified model of the ...
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Article
The migration of cells in multicell tumor spheroids
A mathematical model is proposed to explain the observed internalization of microspheres and 3H-thymidine labelled cells in steady-state multicellular spheroids. The model uses the conventional ideas of nutrient ...