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Article
Direct visualization of the three-dimensional shape of skyrmion strings in a noncentrosymmetric magnet
Magnetic skyrmions are topologically stable swirling spin textures that appear as particle-like objects in two-dimensional (2D) systems. Here, utilizing scalar magnetic X-ray tomography under applied magnetic ...
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Article
Transferrin facilitates the formation of DNA double-strand breaks via transferrin receptor 1: the possible involvement of transferrin in carcinogenesis of high-grade serous ovarian cancer
Fallopian tubal epithelium is a candidate for the origin of high-grade serous ovarian cancer. Transferrin-containing follicular fluid and/or retrograde menstrual blood are possible risk factors for carcinogene...
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Article
Ceramide limits phosphatidylinositol-3-kinase C2β-controlled cell motility in ovarian cancer: potential of ceramide as a metastasis-suppressor lipid
Targeting cell motility, which is required for dissemination and metastasis, has therapeutic potential for ovarian cancer metastasis, and regulatory mechanisms of cell motility need to be uncovered for develop...
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Article
Marrow stromal cells induce B7-H1 expression on myeloma cells, generating aggressive characteristics in multiple myeloma
Tumor-associated B7-H1 molecules inhibit antitumor immunity in some malignancies. We found that B7-H1 expression on patient myeloma cells and human myeloma cell lines (HMCLs) was upregulated by cultivating the...
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Article
Open AccessClinical significance of miR-144-ZFX axis in disseminated tumour cells in bone marrow in gastric cancer cases
We previously reported that bone marrow (BM) was a homing site for gastric cancer (GC) cells leading to haematogenous metastases. There has been little study that microRNAs regulated pathways in malignant cell...
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Article
Open AccessKRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer
This study examined the status of KRAS and BRAF mutations, in relation to extracellular signal-regulated protein kinase (ERK) activation in 58 ovarian carcinomas to clarify the clinicopathological and prognostic ...
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Article
Follow-Up Assessment of the Collateral Circulation in Patients with Kawasaki Disease Who Underwent Dipyridamole Stress Technetium-99m Tetrofosmin Scintigraphy
To assess the alteration of myocardial ischemic findings and the role of collateral vessels in patients with Kawasaki disease (KD), we used dipyridamole stress technetium-99m tetrofosmin (Tf) single photon emi...
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Article
Inhibition of neointimal hyperplasia after balloon injury by cis-element ‘decoy’ of early growth response gene-1 in hypercholesterolemic rabbits
Early growth response factor-1 (Egr-1) is a transcription factor that is rapidly activated after vascular injury and thus might contribute to vascular proliferation and inflammation. We hypothesized that Egr-1...
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Article
Open AccessPercentage of the positive area of bone metastasis is an independent predictor of disease death in advanced prostate cancer
We addressed in this study whether quantifying the extent of disease on bone scans can predict the disease death of patients with advanced prostate cancer using computer-assisted image analysis. Pretreatment r...
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Article
Assessment of the Ability of Myocardial Contrast Echocardiography with Harmonic Power Doppler Imaging to Identify Perfusion Abnormalities in Patients with Kawasaki Disease at Rest and During Dipyridamole Stress
The aim of our study was to assess the ability of myocardial contrast echocardiography (MCE) with harmonic power Doppler imaging (HPDI) to identify perfusion abnormalities in patients with Kawasaki disease at ...
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Chapter
Bioactive Components of a Peruvian Herbal Medicine, Chucuhuasi (Maytenus amazonica)
With a view to the efficient and sustainable use of natural resources, we have studied the pharmacological effects and active components of traditional medicines to gain scientific understanding and develop ra...
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Article
Characterization of Ta2O5 Thin Films with Small Current Leakage for High Density Drams
We have confirmed that grain boundaries are related to leakage problems in Ta2O5/SiON capacitors for high dielectric DRAMs. XRD studies using an intensity ratio of (200) to (001) showed that the crystallographic ...
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Article
Interferon α therapy for chronic active hepatitis type C after renal transplantation and allograft rejection
An acute type rejection episode occurred in one of two patients treated with Interferon α (IFN α) for type C hepatitis (CHC).
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Article
Serum and urinary neopterin as markers in renal transplant patients
For monitoring neopterin levels, serial serum and urinary samples were obtained from 21 renal transplant patients. In renal transplant patients, serum neopterin levels were significantly higher than in healthy...
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Chapter and Conference Paper
Control of humoral and cellular immunity-mediated accelerated heart allograft rejection in sensitized rats by low dose FK 506 and splenectomy
ACI heart grafts are rejected, at an accelerated pace, in Lewis (LEW) rats sensitized by donor-type blood admixed with immunoadjuvant (adjuvant complete Freund, ACF) 7 days earlier. In an in vitro study, the a...
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Chapter and Conference Paper
FK506 mechanism of nephrotoxicity: stimulatory effect on endothelin secretion by cultured kidney cells
The administration of FK506 or cyclosporin A (CyA) to animals and humans induces a decrease in glomerular filtration rate and renal plasma flow and an increase in renal vascular resistance. Endothelins (ET-1),...
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Chapter and Conference Paper
Cellular mechanisms: Induction of heart allograft survival in rats by 15-deoxyspergualin
Survival of ACI rat heart grafts in Lewis rat (LEW) recipients treated with a short course of 15-deoxyspergualin (DSG), in a dose of 5 mg/kg daily beginning from day 4 of grafting, was markedly prolonged, with...
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Chapter and Conference Paper
The Effect of Reduction on the Hall Effect in Nd2-xCexCuO4-δ
We have found that the sign of the Hall coefficient in Nd2-xCexCuO4-δ remains negative at all temperatures for superconducting samples with x=0.15 but that for larger x, the sign of the Hall coefficient in superc...
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Chapter and Conference Paper
Nonspecific hemolytic effector of activated macrophages as activation marker of allograft rejection
The aim was to assess a nonspecific hemolytic effector of activated monocytes/macrophages, designated spontaneous plaque-forming cell (SPFC), as an activation marker in allograft rejection. An in vitro study o...
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Chapter and Conference Paper
In vitro FK506 kidney tubular cell toxicity
Nephrotoxicity is the most prominent side effect of the new immunosuppressive drug FK506. Some of the histopathological changes associated with cyclosporine (CyA) nephrotoxicity such as tubular vacuolization a...
