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Chapter
IDD3 and IDD5 Alleles From Nod Mice Mediate Sjögren’s Syndrome-Like Autoimmunity
Sjögren’s syndrome (SS) is a chronic autoimmune disorder clinically manifested as dry eyes and dry mouth in human patients. The loss of secretory capacity of the eyes and salivary glands presumably results fro...
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Chapter
Immunogenetics of Autoimmune Exocrinopathy in the Nod Mouse: More Than Meets the Eye
Sjögren’s syndrome is defined as a chronic inflammatory autoimmune disorder primarily affecting the lacrimal and salivary exocrine glands. However, the disorder has also been associated with numerous extraglan...
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Chapter
Utilization of the Non-Obese Diabetic (NOD) Mouse as an Animal Model for the Study of Secondary Sjögren’s Syndrome
Sjögren’s syndrome (S.S.) in the human patient population is an autoimmune inflammatory disease presenting clinical symptoms of xerophthalmia and xerostomia1. This condition predominantly affects women. Most diag...