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Open AccessChanges in fatigue, barriers, and predictors towards physical activity in advanced cancer patients over a period of 12 months—a comparative study
Physical activity (PA) is recommended to improve advanced cancer patients’ (ACP) physical functioning, fatigue, and quality of life. Yet, little is known about ACPs’ attitude towards PA and its influence on fa...
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Article
Open AccessFatigue, barriers to physical activity and predictors for motivation to exercise in advanced Cancer patients
In order to counteract fatigue, physical activity (PA) is recommended for all stages of cancer. However, only few advanced cancer patients (ACP) are physically active. Quantitative data with high numbers of AC...
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Regulation of Proliferation and Invasion in Endometriosis
Endometriosis is a common disease in young women, which affects approximately 6–10% of the female German population. It is defined as endometrium-like glands and stroma cells outside the uterus and can cause s...
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Article
Seminal plasma (SP) induces a rapid transforming growth factor beta 1 (TGFβ1)—independent up-regulation of epithelial–mesenchymal transdifferentiation (EMT) and myofibroblastic metaplasia-markers in endometriotic (EM) and endometrial cells
To study if short-term exposure (2 h and 6 h) of endometrial/endometriotic tissues and cells to 10% seminal plasma (SP) can induce EMT/metaplasia.
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Label-Free Quantitative In Vitro Live Cell Imaging with Digital Holographic Microscopy
Label-free quantitative in vitro imaging of living cell cultures with light microscopy is an important tool for various research fields in the life sciences. Digital holographic microscopy (DHM) provides conta...
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Article
Open AccessImaging for cardiac resynchronisation therapy requires cardiac magnetic resonance
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Open AccessErratum to: Tachyarrhythmia in patients with congenital heart disease: inevitable destiny
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Article
Open AccessTachyarrhythmia in patients with congenital heart disease: inevitable destiny?
The prevalence of patients with congenital heart disease (CHD) has increased over the last century. As a result, the number of CHD patients presenting with late, postoperative tachyarrhythmias has increased as...
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Article
Open AccessPhysicochemical and biological characterization of chitosan-microRNA nanocomplexes for gene delivery to MCF-7 breast cancer cells
Cancer gene therapy requires the design of non-viral vectors that carry genetic material and selectively deliver it with minimal toxicity. Non-viral vectors based on cationic natural polymers can form electros...
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Article
Survivin, a target to modulate the radiosensitivity of Ewing’s sarcoma
Radiotherapy constitutes an essential element in the multimodal therapy of Ewing’s sarcoma. Compared to other sarcomas, Ewing tumors normally show a good response to radiotherapy. However, there are consistent...
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Article
miR-145-dependent targeting of Junctional Adhesion Molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness
Micro RNAs are small non-coding RNAs, which regulate fundamental cellular and developmental processes at the transcriptional and translational level. In breast cancer, miR-145 expression is downregulated compa...
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Article
Selective ETAR antagonist atrasentan inhibits hypoxia-induced breast cancer cell invasion
Tumour hypoxia, being widespread in solid tumours, is related to an increased risk of invasion and metastasis as well as to resistance to chemotherapy and radiotherapy. Hypoxia-inducible factor-1α (HIF-1α) has...
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Article
Open AccessExpression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer
The aim of this study was to investigate the expression of the protein tyrosine phosphatases (PTP) PRL-1, PRL-2, and PRL-3 in human breast cancer and to evaluate its clinical and prognostic significance. PRL-P...
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Article
The ins and outs of yeast vacuole trafficking
Vacuoles are ubiquitous organelles in the fungal and plant kingdoms. They serve a variety of functions and are important for cell homeostasis. A constant turnover of proteins and membranes makes vacuoles dynam...
