67 Result(s)

Article

Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats

Neurodegenerative diseases resulting from expanded repeat sequences of glutamine residues are associated with the formation of protein aggregates in the cell nuclei of the affected neurons, but whether these a...

M. F. Perutz, A. H. Windle in Nature (2001)

Article

Will biomedicine outgrow support?

The number of scientists in the biomedical field is growing exponentially at rates that outstrip funding. The present system of short-term research grants, resulting in armies of postdocs without career prospe...

M. F. Perutz in Nature (1999)

Article

Mutations make enzyme polymerize

M. F. Perutz in Nature (1997)

Article

Taking the pressure off

M. F. Perutz in Nature (1996)

Article

Cause of the Root effect in fish haemoglobins

The unusual properties of the Root effect haemoglobins in teleost fish—which allow them to pump O₂ into their swim bladders and eyes against very high pressures—are illuminated in a new fish haemoglobin structure...

M.F. Perutz in Nature Structural Biology (1996)

Article

The chloride effect in human hemoglobin: A new kind of allosteric mechanism

In human hemoglobin hydrogen ions, chloride, 2,3-diphosphoglycerate and CO₂ cooperate to shift the oxygen equilibrium curve to the right. Bovine hemoglobin, by contrast, has an intrinsically low oxygen affinity: ...

M. F. Perutz in Experientia (1995)

Article

Of squids and radar

Chance and Design: Reminiscences of Science in Peace and War.

M. F. Perutz in Nature (1992)

Article

Molecular inventiveness

M. F. Perutz in Nature (1990)

Article

Buchbesprechungen

P. F. Tschudin, L. Jaenicke, H. Autrum, M. F. Perutz in The Science of Nature (1989)

Chapter and Conference Paper

Mechanisms Regulating the Reactions of Human Hemoglobin with Oxygen and Carbon Monoxide

The reactions of hemoglobin with oxygen and carbon monoxide are subject to regulation by the heme and the residues surrounding it and by the effectors, also known as heterotopic ligands (H⁺, Cl^-, CO₂, and 2,3-dip...

M. F. Perutz in Clinical Aspects of O₂ Transport and Tissue Oxygenation (1989)

Article

Control by phosphorylation

M. F. Perutz in Nature (1988)

Article

Physics and the riddle of life

Erwin Schrödinger's book What is Life?, published in 1944, drew several of the brightest physicists into molecular biology. But the book's chief merit lies in its rescue from obscurity and popularization of a...

M. F. Perutz in Nature (1987)