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Article
Comparison of PET/CT and PET/MRI hybrid systems using a 68Ga-labelled PSMA ligand for the diagnosis of recurrent prostate cancer: initial experience
68Ga-labelled HBED-CC-PSMA is a highly promising tracer for imaging recurrent prostate cancer (PCa). The intention of this study was to evaluate the feasibility of PET/MRI with this tracer.
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Article
Reply to Reske et al.: PET imaging with a [68Ga]gallium-labelled PSMA ligand for the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumour lesions
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Article
Erratum to: PET imaging with a [68Ga]gallium-labelled PSMA ligand for the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumour lesions
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Article
PET imaging with a [68Ga]gallium-labelled PSMA ligand for the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumour lesions
Prostate-specific membrane antigen (PSMA) is a cell surface protein with high expression in prostate carcinoma (PC) cells. Recently, procedures have been developed to label PSMA ligands with 68Ga, 99mTc and 123/1...
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Article
[68Ga]Gallium-labelled PSMA ligand as superior PET tracer for the diagnosis of prostate cancer: comparison with 18F-FECH
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Chapter and Conference Paper
Molecular Imaging of Tumor Metabolism and Apoptosis
Increased metabolism has been found to be one of the most prominent features of malignant tumors. This property led to the development of tracers for the assessment of glucose metabolism a...
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Article
Comparison of 68Ga-DOTATOC PET and 111In-DTPAOC (Octreoscan) SPECT in patients with neuroendocrine tumours
Neuroendocrine tumours (NETs) can be imaged with scintigraphy using radiolabelled somatostatin analogues. The aim of our study was to compare the value of 68Ga-DOTATOC PET and 111In-DTPAOC SPECT (Octreoscan) in t...
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Article
Open AccessCharacteristic abnormalities in cerebrospinal fluid biochemistry in children with cerebral malaria compared to viral encephalitis
In develo** countries where Plasmodium falciparum malaria is endemic, viral encephalitis and cerebral malaria are found in the same population, and parasitemia with Plasmodium falciparum is common in asymptomat...
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Article
Cerebrospinal Fluid Adenosine Deaminase Levels and Adverse Neurological Outcome in Pediatric Tuberculous Meningitis
There is a lack of data on the prognostic significance of changes in cerebrospinal fluid (CSF) parameters in tuberculous meningitis. Our objective was to determine whether changes in CSF parameters are associa...
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Article
Open AccessPhase I clinical trial of the bispecific antibody MDX-H210 (anti-FcγRI × anti-HER-2/neu) in combination with Filgrastim (G-CSF) for treatment of advanced breast cancer
A phase I study of the bispecific antibody MDX-H210 in combination with granulocyte colony-stimulating factor (G-CSF) was performed in stage IV breast carcinoma patients, overexpressing HER-2/neu. MDX-H210, co...
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Article
Cerebrospinal Fluid Glucose Levels and Sensorineural Hearing Loss in Bacterial Meningitis
Background: Low cerebrospinal fluid (CSF) glucose levels have been associated with sensorineural hearing loss (SNHL) in bacterial meningitis but systematic investigations are lacking.
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Article
Enhanced iodide transport after transfer of the human sodium iodide symporter gene is associated with lack of retention and low absorbed dose
Transfer of the sodium iodide symporter (hNIS) has been proposed as a new principle of cancer gene therapy. Using clinically relevant doses of 131I for the treatment of NIS-expressing prostate carcinoma cells, we...
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Article
99mTcO(BAT-NI), a novel nitroimidazole tracer: in vivo uptake studies in ischaemic myocardium
Myocardial perfusion single-photon emission tomography (SPET) performed with cationic technetium-99m complexes indicates ischaemic areas as cold lesions. By contrast, nitroimidazole derivatives labelled with f...
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Article
Ultrastructure of the vitelline coat in the ascidians Phallusia mammillata, Ascidia mentula and Ciona intestinalis : new aspects revealed by freeze-substitution and deep-etching
The microstructure of the vitelline coat (VC) of the three ascidian species Phallusia mammillata, Ascidia mentula and Ciona intestinalis was analyzed by transmission electron microscopy (TEM) using freeze-substi...
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Chapter and Conference Paper
Travel-related vector-borne virus infections in Germany
Laboratory diagnosis of imported, vector-borne virus diseases during a 22-month-period in Munich, Germany, is summarized. In 13/317 Germans returning from the Mediterranean with suspected sandfly fever, acute ...
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Article
Buchbesprechungen
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Chapter and Conference Paper
Therapy of Carcinoid Tumors with [131I] Meta-Iodo-Benzyl-Guanidine
Meta-iodo-benzyl-guanidine (MIBG) is a pharmaceutical with structural similarity to norepinephrine. It was introduced by Sisson et al. in 1981 as a pheochromocytoma scanning agent [8]. The intense and highly s...
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Chapter
Strahlenbiologie
Bei der Wechselwirkung von Röntgen- und γ-Strahlung mit biologischer Materie werden energiereiche Elektronen freigesetzt. Die physikalischen Mechanismen, aus denen diese mit kinetischer Energie behafteten Elek...
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Chapter and Conference Paper
Selektive nuklearmedizinische Therapie mit meta-Jod-Benzylguanidin
Grundlage jeder nuklearmedizinischen Therapie ist die Applikation eines Radionuklides mit Strahlung von kurzer Reichweite direkt in den Krankheitsherd oder in seine unmittelbare Umgebung. Die eleganteste Form ...
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Chapter and Conference Paper
Neues Radiopharmakon zur simultanen Beurteilung der Transplantatperfusion und der -funktion
In vielen Transplantationszentren werden u.a. zur Verifizierung einer akuten Tubulusnekrose, zur frühzeitigen Erkennung einer Abstoßungsreaktion und auch zur Differenzierung von einer Ciclosporin-Nephrotoxizit...