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Article
Open AccessEducating health professionals to optimise falls screening in hospitals: protocol for a mixed methods study
Falls in hospitals remain a major challenge to patient safety. All hospitalised adults are at risk of falling during their inpatient stay, though this risk is not always realised by patients and clinicians. Th...
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Article
Optimum HPLC parameters for simultaneous determination of Robinin and Kaempferol
An HPLC method for simultaneous quantitative determination of robinin and its aglycone kaempferol in MCF-7 human breast carcinoma cell line was developed. Robinin and kaempferol were separated using a Platinum...
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Article
Molecular Mechanisms in Renal and Intestinal Sulfate (Re)Absorption
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Article
Detection and quantitation of a sodium-dependent sulfate cotransporter (NaSi-1) by sandwich-type enzyme-linked immunosorbent assay
The sodium-dependent sulfate transporter (NaSi-1) DNA has been recently identified from rat kidney cortex. The objective of this study was to develop a quantitative assay for the NaSi-1 transporter protein. T...
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Article
Extracellular K+ accumulations and synchronous GABA-mediated potentials evoked by 4-aminopyridine in the adult rat hippocampus
Transient changes in extracellular potassium concentration ([K+]0) and field potentials were evoked by 4-aminopyridine (4-AP; 50–100 μM) and recorded with ion-selective microelectrodes in CA1b, CA3b and dentate s...
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Chapter
“Nouvelle Design”: A Pragmatic Approach to CSCW Systems Building
Recent growing interest in Computer Supported Cooperative Work (CSCW), is highlighting deficiencies in the classical software development process, and is demanding new tools, processes and techniques. This cha...
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Article
Changes in extracellular K+ evoked by GABA, THIP and baclofen in the guinea-pig hippocampal slice
Changes in [K+]0 evoked by the inhibitory amino acid transmitter, GABA (γ-aminobutyric acid) and its agonists were recorded with ion-selective microelectrodes in the CA1 stratum pyramidale of guinea-pig hippocamp...
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Article
Effects of ketamine on GABA-evoked excitability of peripheral nerve
The effects of the dissociative anaesthetic, ketamine on GABA-evoked changes in the excitability of myelinated fibers of dorsal and ventral roots of isolated bullfrog sciatic nerves were examined. Ketamine alo...
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Article
Intracellular calcium in mammalian brain cells: fluorescence measurements with quin2
Dispersed brain cells from 12–14 day old mouse embryos were loaded with the Ca2+-sensitive fluorescent probe, quin2 and shown to have a resting intracellular Ca2+ concentration ([Ca2+]i) of 158 nM (SE ± 5) in the...
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Article
Lathyrus excitotoxin: mechanism of neuronal excitation by L-2-oxalylamino-3-amino- and L-3-oxalylamino-2-amino-propionic acid
Intracellular recordings were made in cultured neurones from foetal mouse spinal cord. The effects of applications of the neurotoxin, L-3-oxalylamino-2-amino-propionic acid (a constituent of the chickling pea, La...
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Article
Book reviews
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Chapter
Some effects of picrotoxin on afferent terminals in the cuneate nucleus of the cat
The slow potentials recorded from dorsal roots or from the dorsal region of the spinal cord have been explained as the result of the operation of two very different mechanisms. The first was suggested by Barro...
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Article
Sympatho-adrenal responses during general anaesthesia in the dog and man
Plasma catecholamine levels were studied during general anaesthesia with diethyl ether, cyclopropane, and halothane in dogs and human subjects. Anaesthesia with ether/oxygen caused highly significant increases...
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Article
A study of methoxyflurane anaesthesia
Methoxyflurane anaesthesia in dogs produced respiratory depression, a gradual moderate decline in blood pressure with minimal changes in heart rate, and no significant effect on blood glucose or plasria adrena...
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Article
Induced sympathetic stimulation during halothane anaesthesia
In an attempt to assess the sympathoadrenal responses to hypercarbia and haemorrhage during halothane anaesthesia, plasma adrenalin and noradrenalin concentrations were determined in dogs maintained in a stead...