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  1. Article

    Repetitive Transcranial Magnetic Stimulation Increases the Release of Dopamine in the Nucleus Accumbens Shell of Morphine-Sensitized Rats During Abstinence

    Recent studies in rodents have shown that withdrawal from chronic drug abuse is associated with a significant decrease in dopamine (DA) release in mesolimbic structures, especially in the shell region of the n...

    A Erhardt, I Sillaber, T Welt, M B Müller, N Singewald, M E Keck in Neuropsychopharmacology (2004)

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    Chapter

    Mutagenesis and Knockout Models: Hypothalamic-Pituitary-Adrenocortical System

    Hyperactivity of central neuropeptidergic circuits such as the corticotropin-releasing hormone (CRH) and vasopressin (AVP) neuronal systems is thought to play a causal role in the etiology and symptomatology o...

    M.E. Keck, M.B. Müller in Anxiety and Anxiolytic Drugs (2005)

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    Chapter

    Challenge Studies in Anxiety Disorders

    In psychiatry, the use of pharmacological challenges in panic disorder is unique in that the clinical phenomenon of central interest (i.e., the panic attack) can be provoked readily and assessed in the clinica...

    M.E. Keck, A. Ströhle in Anxiety and Anxiolytic Drugs (2005)

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    Article

    Endocrine disturbances in depression

    Depression is one of the most common psychiatric disorders. For a long time, clinicians suspected a causal link between depression and the endocrine system. The most frequently occurring endocrine abnormality ...

    M. A. Tichomirowa MD, M. E. Keck… in Journal of Endocrinological Investigation (2005)

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    Article

    Corticotropin-releasing factor, vasopressin and receptor systems in depression and anxiety

    Affective disorders tend to be chronic and life-threatening diseases: suicide is estimated to be the cause of death in 10–15% of individuals with major depressive disorders. Major depression is one of the most...

    M. E. Keck in Amino Acids (2006)

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    Chapter and Conference Paper

    Transcranial magnetic stimulation patterns in heterogeneous brain tissue: focality, reproducibility and true sham stimulation

    Transcranial magnetic stimulation (TMS) has been gaining status as an innovative research and possibly therapeutic tool for non-invasive stimulation of brain tissue. However, optimal values of key stimulation ...

    Nicola Toschi, M. Guerrisi, T. Welt… in World Congress on Medical Physics and Biom… (2007)

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    Article

    Association of polymorphisms in the angiotensin-converting enzyme gene with syndromal panic attacks

    A Erhardt, S Lucae, N Kern, P G Unschuld, M Ising, R Lieb, M Uhr… in Molecular Psychiatry (2008)

  8. Article

    Open Access

    The GABA transporter 1 (SLC6A1): a novel candidate gene for anxiety disorders

    Recent evidence suggests that the GABA transporter 1 (GAT-1; SLC6A1) plays a role in the pathophysiology and treatment of anxiety disorders. In order to understand the impact of genetic variation within SLC6A1...

    C. K. Thoeringer, S. Ripke, P. G. Unschuld, S. Lucae… in Journal of Neural Transmission (2009)

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    Article

    TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies

    The lifetime prevalence of panic disorder (PD) is up to 4% worldwide and there is substantial evidence that genetic factors contribute to the development of PD. Single-nucleotide polymorphisms (SNPs) in TMEM13...

    A Erhardt, L Czibere, D Roeske, S Lucae, P G Unschuld, S Ripke… in Molecular Psychiatry (2011)