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Article
TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies
The lifetime prevalence of panic disorder (PD) is up to 4% worldwide and there is substantial evidence that genetic factors contribute to the development of PD. Single-nucleotide polymorphisms (SNPs) in TMEM13...
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Article
Open AccessThe GABA transporter 1 (SLC6A1): a novel candidate gene for anxiety disorders
Recent evidence suggests that the GABA transporter 1 (GAT-1; SLC6A1) plays a role in the pathophysiology and treatment of anxiety disorders. In order to understand the impact of genetic variation within SLC6A1...
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Article
Association of polymorphisms in the angiotensin-converting enzyme gene with syndromal panic attacks
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Chapter and Conference Paper
Transcranial magnetic stimulation patterns in heterogeneous brain tissue: focality, reproducibility and true sham stimulation
Transcranial magnetic stimulation (TMS) has been gaining status as an innovative research and possibly therapeutic tool for non-invasive stimulation of brain tissue. However, optimal values of key stimulation ...
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Article
Corticotropin-releasing factor, vasopressin and receptor systems in depression and anxiety
Affective disorders tend to be chronic and life-threatening diseases: suicide is estimated to be the cause of death in 10–15% of individuals with major depressive disorders. Major depression is one of the most...
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Article
Endocrine disturbances in depression
Depression is one of the most common psychiatric disorders. For a long time, clinicians suspected a causal link between depression and the endocrine system. The most frequently occurring endocrine abnormality ...
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Chapter
Mutagenesis and Knockout Models: Hypothalamic-Pituitary-Adrenocortical System
Hyperactivity of central neuropeptidergic circuits such as the corticotropin-releasing hormone (CRH) and vasopressin (AVP) neuronal systems is thought to play a causal role in the etiology and symptomatology o...
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Chapter
Challenge Studies in Anxiety Disorders
In psychiatry, the use of pharmacological challenges in panic disorder is unique in that the clinical phenomenon of central interest (i.e., the panic attack) can be provoked readily and assessed in the clinica...
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Article
Repetitive Transcranial Magnetic Stimulation Increases the Release of Dopamine in the Nucleus Accumbens Shell of Morphine-Sensitized Rats During Abstinence
Recent studies in rodents have shown that withdrawal from chronic drug abuse is associated with a significant decrease in dopamine (DA) release in mesolimbic structures, especially in the shell region of the n...