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  1. No Access

    Article

    Brain aging phenomena in migrating sockeye salmon Oncorhynchus nerka nerka

    Aging, a process occuring in all vertebrates, is closely related to a loss in physical and functional abilities. There is widespread interest in clarifying the relevance of environmental, metabolic, and geneti...

    M. E. Götz, C. R. Malz, A. Dirr, D. Blum, W. Gsell… in Journal of Neural Transmission (2005)

  2. No Access

    Article

    (r)-, but not (s)-alpha lipoic acid stimulates deficient brain pyruvate dehydrogenase complex in vascular dementia, but not in Alzheimer dementia

    In dementia of Alzheimer type (DAT), cerebral glucose metabolism is reduced in vivo, and enzymes involved in glucose breakdown are impaired in post-mortem brain tissue. Pyruvate dehydrogenase complex activity (PD...

    L. Frölich, M. E. Götz, M. Weinmüller, M. B. H. Youdim… in Journal of Neural Transmission (2004)

  3. No Access

    Chapter

    Formation of Radicals

    Cerebral formation of oxygen and nitrogen centered radicals including superoxide, hydroxyl radical, nitric oxide, and peroxynitrite is a physiological process originating from enzyme catalyzed redox reactions ...

    M. E. Götz, M. Gerlach in Brain Damage and Repair (2004)

  4. No Access

    Article

    Methylmercury induces neurite degeneration in primary culture of mouse dopaminergic mesencephalic cells

    Methylmercury cation (MeHg) is an hazardous environmental pollutant with neurotoxic action. Little is known about the effects of MeHg on catecholaminergic neurons. In the present study we have used epifluores...

    M. E. Götz, E. Koutsilieri, P. Riederer, S. Ceccatelli… in Journal of Neural Transmission (2002)

  5. No Access

    Article

    Monoamine oxidase-inhibition and MPTP-induced neurotoxicity in the non-human primate: comparison of rasagiline (TVP 1012) with selegiline

    The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been shown to induce parkinsonism in man and non-human primates. Monoamine-oxidase B (MAO-B) has been reported to be implicated in both M...

    A. Kupsch, J. Sautter, M. E. Götz, W. Breithaupt… in Journal of Neural Transmission (2001)

  6. No Access

    Article

    Altered redox state of platelet coenzyme Q10 in Parkinson's disease

    Background. The reduced form of coenzyme Q10 (CoQ10) acts as a lipophilic antioxidant and participates in electron and proton transport of the respiratory chain in the inner mitochondrial membrane. An alteration...

    M. E. Götz, A. Gerstner, R. Harth, A. Dirr, B. Janetzky… in Journal of Neural Transmission (2000)

  7. No Access

    Article

    Acetylcholine in human CSF: methodological considerations and levels in dementia of Alzheimer type

    Four different methods to measure acetylcholine (ACh) and choline (Ch) concentration, i.e. thermospray/mass spectroscopy (TS/MS), high pressure liquid chromatography/mass spectroscopy (HPLC/MS), high pressure...

    L. Frölich, A. Dirr, M. E. Götz, W. Gsell, H. Reichmann… in Journal of Neural Transmission (1998)

  8. No Access

    Chapter and Conference Paper

    „Nicht-Amyloid“-Hypothesen zur Ätiopathogenese der Demenz vom Alzheimer Typ (DAT)

    Demographische Betrachtungen. Der Altersaufbau der Bevölkerung Deutschlands hat sich im letzten Jahrhundert stark verändert. Nach koordinierten Vorausberechnungen hält dieser Trend an und es werden...

    Prof. Dr. Dipl.-Ing. W. Gsell, D. Blum-Degen… in Aktuelle Perspektiven der Biologischen Psy… (1996)

  9. No Access

    Article

    Abstracts Second Congress of the European Society for Clinical Neuropharmacology

    Y. Agid, T. Arendt, U. Gärtner, M. Holzer… in Journal of Neural Transmission / General S… (1995)

  10. No Access

    Chapter and Conference Paper

    Neurochemical investigations in patients with dementia of Alzheimer type and their clinical value

    The clinical diagnosis of dementia of Alzheimer type (DAT) relies on the identification of a dementia syndrome in the absence of other known etiologies, which results in a diagnostic validity of approximately ...

    Dr. L. Frölich, A. Dirr, M. E. Götz… in New Trends in the Diagnosis and Therapy of… (1994)

  11. No Access

    Chapter

    Oxidative stress: a role in the pathogenesis of Parkinson’s disease

    The degeneration of nigro-striatal dopaminergic neurons is considered to be a predominant pathogenetic factor of Parkinson’s disease (PD). However, the etiology of this degeneration is not known. Hypotheses as...

    M. E. Götz, A. Freyberger… in Neurotransmitter Actions and Interactions (1990)