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Article
Open AccessDopamine cross-sensitization between psychostimulant drugs and stress in healthy male volunteers
Dysregulation of the stress response system is a potential etiological factor in the development of and relapse to multiple neuropsychiatric disorders. Previously we reported that repeated intermittent d-amphetam...
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Article
Tryptophan hydroxylase2 gene polymorphisms predict brain serotonin synthesis in the orbitofrontal cortex in humans
Brain regional serotonin synthesis can be estimated in vivo using positron emission tomography (PET) and α-[(11)C]methyl-L-tryptophan (11C-AMT) trap** (K*) as a proxy. Recently, we reported evidence of lower no...
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Article
Stereospecific synthesis of α-methylated amino acids
Both 2,5-trans and 2,5-cis disubstituted 2-tert-butyl-5-(indol-3-yl)methylimidazolidin-4-ones were synthesised and their enolates were prepared using LDA. While the enolate of the 2,5-trans disubstituted deri...
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Article
Chronological study of peripheral benzodiazepine binding sites in the rat brain stab wounds using [3H] PK-11195 as a marker for gliosis
Chronological studies of the development of the peripheral benzodiazepine receptor sites were undertaken with the goal of evaluating the sensitivity of this marker for the study of the gliosis development in t...
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Article
Pharmacokinetics of 11C-labelled BCNU and SarCNU in gliomas studied by PET
This paper describes the study of the pharmacodynamics of two 11C-labelled nitrosoureas, 1,3-bis-(2-chloroethyl) nitrosourea (BNCU) and sarcosinamide chloroethylnitrosourea (SarCNU), both labelled in the carbonyl...
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Chapter
Autoradiographic Measurement of the Rate of Serotonin Synthesis in the Rat Brain
The rate of serotonin synthesis has hitherto been measured by two different methodological approaches, steady- and nonsteady-state. In these methods, the rate of synthesis is estimated from the change in the c...
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Article
Synthesis of “no-carrier-added”11C-labelled nitrosoureas
This paper decribes syntheses for the11C-labelled chemotherapeutic drug, CCNU,11C-labelled BFNU and CFNU (analogs of BCNU) as well as an improved synthesis for11C-BCNU. Also discussed are procedures for the separ...
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Chapter and Conference Paper
Focal Flow Disturbances in Acute Strokes: Effects on Regional Metabolism and Tissue pH
In acute stroke, the reduction of blood flow causes tissue damage and sets of a complex escalating chain reaction from acid metabolites and also from products of disturbed intracellular ionic homeostasis. Thes...
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Chapter and Conference Paper
Changes of Energy Metabolism and Regional Cerebral Blood Flow Studied by Positron Emission Tomography in the Interictal Phase of Partial Epilepsy
We report here results of positron emission tomographic studies on 14 patients with partial epilepsy using fluorine-18 labelled fluorodeoxyglucose for regional cerebral metabolic rate for glucose (rCMRGl) and ...
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Chapter
Regional Cerebral Blood Flow Measurement and Dynamic Positron Emission Tomography
Over the past few years several positron emission tomographic techniques (PET) have been introduced for quantitative measurement of regional cerebral blood flow (rCBF). Quantitative rCBF measurement by PET can...
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Article
A new reagent for the visualisation of N-alkylureas on TLC plates
A new reagent for the visualisation of substituted ureas on TLC plates byin situ nitrosation is described. The procedure involves spraying the plates with two different reagents, and takes about five minutes. The...
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Article
A comparison of the statistical treatment of results using concentrations of elements determined by neutron activation and X-ray fluorescence analysis methods
Statistical treatment was carried out using the elements determined both by neutron activation and X-ray fluorescence analysis in order to decide on the method to be used in the future work.
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Article
Activation analysis of Turkish and Canadian clays and Turkish pottery
Activation analysis of Canadian and Turkish clays showed that the elements Cs, Th, Sc, Hf, Ta and Co were the most useful elements to study in order to obtain a differentiation by multivariate analysis. The sa...
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Article
Studies on precipitation and co-precipitation of tantalum and niobium from potassium fluoride solutions
Precipitation and co-precipitation of tantalum and niobium from KF solution were investigated under various experimental conditions. Results obtained indicate that variations of HF concentration do not influen...
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Chapter and Conference Paper
The M2/E1 Mixing Ratio for the Anomalous ΔK = 1 71.6 keV Transition in 177 Hf
In the region of deformed nuclei, the weak M2 transitions compete with the El transitions which are considerably slowed down. The M2 admixtures are mostly deduced from internal conversion coefficients. However...
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Article
Directional correlation studies in the decay of177gLu
Directional gamma-gamma correlations of the strong 208.4–112.9 keV and of the weak 71.6–249.7 keV cascade transitions in the decay of177gLu have been measured. The correlation coefficientsA 22=−0.208±0.012 of the...
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Article
Additional measurements of the radiative capture cross sections for 3 MeV neutrons
The cross-sections for63Cu,74Ge,75As,80Se,81Br,130Te,141Pr,186W,209Bi(n, γ) reactions have been measured at 3 MeV. The results are in agreement with earlier measurements and follow the general trend observed in t...
