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  1. No Access

    Chapter

    Inhibitory Effects of Roquefortine on Hepatic Cytochromes P450

    Roquefortine, a cyclodipeptide derived from the diketopiperazine cyclo (TrpdehydroHis), is a secondary metabolite produced by some Penicillium species (1,2). P. roqueforti is considered as one of the most importa...

    C. Aninat, M. Delaforge in Biological Reactive Intermediates VI (2001)

  2. No Access

    Article

    Immunostimulating lipopeptide, LtriP (RP 56142): Comparison of the effect on hepatic cytochrome P 450 modulation and radioprotection in male and female of three mouse strains

    The sex-dependent effect of lauroyl-L-Ala-D-γ-Glu-L,L-A2pmNH2 (LtriP, RP 56142) on hepatic microsomal cytochromes P 450 (cyt P 450) was studied in three mouse strains NMRI, C3H/OuJ and C3H/HeJ. In NMRI and C3H/Ou...

    M. Sedqi, M. Delaforge, D. Mansuy, B. Martin, P. Jollès, D. Migliore-Samour in Experientia (1995)

  3. No Access

    Article

    In vivo effects of immunostimulating lipopeptides on mouse liver microsomal cytochromes P-450 and on paracetamol-induced toxicity

    Immunomodulating lipopeptides lauroyl-L-Ala-γ-D-Glu-LL-A2pmNH2-Gly (RP 44.102) and lauroyl-L-Ala-γ-D-Glu-LL-A2pmNH2 (RP 56.142) were found to protect mice against the hepatotoxicity of paracetamol, which is du...

    D. Migliore-Samour, M. Delaforge, M. Jaouen, D. Mansuy, P. Jollès in Experientia (1989)

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    Chapter and Conference Paper

    Ligand Binding of Safrole to Cytochrome P-450

    Safrole, a hepatocarcinogen, is converted by the microsomal mono-oxygenase system to a reactive intermediate which interacts with cytochrome P-450 to form a ligand complex. The formation of this complex is acc...

    M. Delaforge, C. Ioannides, D. V. Parke in Further Studies in the Assessment of Toxic… (1980)

  5. No Access

    Chapter

    Direct Evidence of Epoxide Metabolic Pathway for Natural Allylbenzene Compounds in Adult Rat Liver Cell Culture

    Natural allylbenzene compounds are widely used as components of insecticides, food additives and pharmaceutical preparations. The presence of safrole and eugenol in food is listed in Table 1. Safrole (4-allyl-...

    M. Delaforge, P. Janiaud, B. F. Maume… in Recent Developments in Mass Spectrometry i… (1978)