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  1. No Access

    Article

    Mobilization studies in complement-deficient mice reveal that optimal AMD3100 mobilization of hematopoietic stem cells depends on complement cascade activation by AMD3100-stimulated granulocytes

    We reported that complement cascade (CC) becomes activated in bone marrow (BM) during mobilization of hematopoietic stem/progenitor cells (HSPCs) induced by granulocyte colony-stimulating factor (G-CSF) and C5...

    H M Lee, M Wysoczynski, R Liu, D-M Shin, M Kucia, M Botto, J Ratajczak… in Leukemia (2010)

  2. No Access

    Article

    A lupus-susceptibility C57BL/6 locus on chromosome 3 (Sle18) contributes to autoantibody production in 129 mice

    Epistatic interactions between the non-autoimmune strains 129 and C57BL/6 (B6), used for generating gene-targeted animals, can induce a lupus-like disease. Genome-wide scan analyses of testcross progeny betwee...

    Y Heidari, L Fossati-Jimack, F Carlucci, M J Walport, H T Cook, M Botto in Genes & Immunity (2009)

  3. No Access

    Article

    Identification of chromosome intervals from 129 and C57BL/6 mouse strains linked to the development of systemic lupus erythematosus

    Systemic lupus erythematosus is an autoimmune disease in which complex interactions between genes and environmental factors determine the disease phenotype. We have shown that genes from the non-autoimmune str...

    Y Heidari, A E Bygrave, R J Rigby, K L Rose, M J Walport, H T Cook… in Genes & Immunity (2006)

  4. No Access

    Article

    Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity

    Serum amyloid P component (SAP), a highly conserved plasma protein named for its universal presence in amyloid deposits1, is the single normal circulating protein that shows specific calcium-dependent binding to ...

    M.C.M. Bickerstaff, M. Botto, W.L. Hutchinson, J. Herbert, G.A. Tennent… in Nature Medicine (1999)