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Article
A randomized clinical study on postoperative pain comparing between the supraglottic airway device and endotracheal tubing in transabdominal preperitoneal repair (TAPP)
Transabdominal preperitoneal (TAPP) repair is the most widely used laparoscopic technique for the treatment of inguinal hernia in Japan. Many studies have shown that in comparison with open hernia repair, lapa...
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Chapter
Evaluation of Pleasure-Displeasure Induced by Use of Lipsticks with Near-Infrared Spectroscopy (NIRS): Usefulness of 2-Channel NIRS in Neuromarketing
In order to examine whether near-infrared spectroscopy (NIRS) would be a useful neuromarketing tool, we employed NIRS to evaluate the difference of pleasure-displeasure in women, induced by the use of differen...
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Article
Deficiency in WT1-targeting microRNA-125a leads to myeloid malignancies and urogenital abnormalities
The Wilms’ tumor gene WT1 is overexpressed in leukemia and solid tumors and has an oncogenic role in leukemogenesis and tumorigenesis. However, precise regulatory mechanisms of WT1 overexpression remain undetermi...
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Article
Navigation surgery for intraoperative sentinel lymph node detection using Indocyanine green (ICG) fluorescence real-time imaging in breast cancer
A new sensitive fluorescence imaging system was developed for the real-time identification of sentinel lymph nodes (SLNs) in patients with early breast cancer. The purpose of this study was to evaluate the uti...
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Article
Treatment of relapsed acute myeloid leukemia with MLL/AF6 fusion after allogeneic hematopoietic stem cell transplantation with gemtuzumab ozogamicin with a long interval followed by donor lymphocyte infusion
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Article
Mechanisms of sperm-egg interactions emerging from gene-manipulated animals
Untangling the molecular nature of sperm-egg interactions is fundamental if we are to understand fertilization. These phenomena have been studied for many years using biochemical approaches such as antibodies ...
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Article
The Wilms’ tumor gene WT1-GFP knock-in mouse reveals the dynamic regulation of WT1 expression in normal and leukemic hematopoiesis
The Wilms’ tumor gene WT1 is overexpressed in most of human leukemias regardless of disease subtypes. To characterize the expression pattern of WT1 during normal and neoplastic hematopoiesis, we generated a knock...
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Article
Akt activation induces epidermal hyperplasia and proliferation of epidermal progenitors
Various common signaling pathways maintain tissue stem cells, including Notch and Wnt/β-catenin signals. Phosphoinositide-3 kinase (PI3K)/Akt signaling regulates the ‘stemness’ of several stem cells in culture, s...
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Article
Polycythemia associated with the JAK2V617F mutation emerged during treatment of chronic myelogenous leukemia
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Article
Adenovirus serotype 35 vector-mediated transduction into human CD46-transgenic mice
We previously demonstrated that systemic administration of adenovirus serotype 35 (Ad35) vectors to mice does not mediate efficient transduction in organs, probably because expression of the mouse analog of th...
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Article
Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells
Embryonic stem (ES) cells can self-renew indefinitely without losing their differentiation ability to any cell types. Phosphoinositide-3 kinase (PI3K)/Akt signaling plays a pivotal role in various stem cell sy...
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Article
Clinical significance of osteopontin in esophageal squamous cell carcinoma: A comparative analysis with generally used tumor markers
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Article
Quantification of minimal residual disease in patients with e1a2 BCR-ABL-positive acute lymphoblastic leukemia using a real-time RT-PCR assay
Using a real-time RT-PCR method, we analyzed the expression of e1a2 BCR-ABL mRNA in bone marrow samples from 13 patients with e1a2 BCR-ABL-positive acute lymphoblastic leukemia (ALL) at different time points d...
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Chapter
Distribution of Copper Transported ATP7B in Embryo and New Born Rat
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Article
Allelic loss of the NF1 gene in anal malignant melanoma in a patient with neurofibromatosis type 1
A 64-year-old man with neurofibromatosis type 1 (NF1) developed a primary malignant melanoma of the anus. Genetic analysis of the resected tumor confirmed loss of heterozygosity (LOH) of the NF1 gene. Anorectal ...
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Article
Green Fluorescent Protein (GFP) as a Marker for Cell Viability After UV Irradiation
Generation of Chinese Hamster Ovary (CHO) cell lines stably expressing green fluorescent protein (GFP) was achieved using a plasmid vector that encoded the red-shifted pCX-xGFP under the control of a strong hy...
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Article
Combined effect of navelbine with medroxyprogesterone acetate against human breast carcinoma MCF-7 cells in vitro
Navelbine (NVB, vinorelbine ditartrate, KW-2307), a new vinca alkaloid analogue, has been shown to be clinically effective against advanced breast cancer. In this report, the combined effect of NVB with medrox...
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Chapter and Conference Paper
Studies on the Mechanism of Sperm Production
Producing functional sperm in mammals requires two steps that take place in two different organs: the production of sperm in the testis and the maturation of sperm in the epididymis. The germ cell differentiat...
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Article
Effects of amino acid replacements on cadmium binding of metallothionein α-fragment
To evaluate whether only 20 cysteine residues at invariant positions are needed to bind and coordinate the metals in metallothioneins (MTs), and whether changing the positions of cysteine residues in the sequ...
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Article
Reversal effect of itraconazole on adriamycin and etoposide resistance in human leukemia cells
Itraconazole is a triazole antifungal agent that inhibits cell membrane serol biosynthesis. Currently, itraconazole is a potent candidate for in vivo use to revert multidrug resistance in acute leukemias, with...
