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    Article

    De novo deleterious genetic variations target a biological network centered on Aβ peptide in early-onset Alzheimer disease

    We hypothesized that de novo variants (DNV) might participate in the genetic determinism of sporadic early-onset Alzheimer disease (EOAD, onset before 65 years). We investigated 14 sporadic EOAD trios first by ar...

    A Rovelet-Lecrux, C Charbonnier, D Wallon, G Nicolas, M N J Seaman… in Molecular Psychiatry (2015)

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    Article

    Membrane traffic in the secretory pathway

    The steady-state localisation of membrane proteins in the endocytic system is the result of many sorting events that occur at various points throughout the endosomal pathway. A protein that has been endocytose...

    M. N. J. Seaman in Cellular and Molecular Life Sciences (2008)