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Article
Open AccessThe thrombopoietin/MPL axis is activated in the Gata1low mouse model of myelofibrosis and is associated with a defective RPS14 signature
Myelofibrosis (MF) is characterized by hyperactivation of thrombopoietin (TPO) signaling, which induces a RPS14 deficiency that de-regulates GATA1 in megakaryocytes by hampering its mRNA translation. As mice c...
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Article
Open AccessPrediction and evaluation of resting energy expenditure in a large group of obese outpatients
The aim of this study was to compare resting energy expenditure (REE) measured (MREE) by indirect calorimetry (IC) and REE predicted (PREE) from established predictive equations in a large sample of obese Cauc...
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Article
Open AccessHematological complications in anorexia nervosa
Anemia, leukopenia and, although less frequently, thrombocytopenia are possible hematological complications of anorexia nervosa considered strictly secondary to chronic malnutrition. This is a retrospective st...
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Article
A plant microfossil record of Late Quaternary environments and human activity from Rano Aroi and surroundings, Easter Island
To investigate past vegetation change and human activity at the highest elevations on Easter Island, this study examines pollen, phytoliths, diatoms, starch and arthropods preserved in sediment/soil profiles ...
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Article
Pollen, phytoliths, arthropods and high-resolution 14C sampling from Rano Kau, Easter Island: evidence for late Quaternary environments, ant (Formicidae) distributions and human activity
A 20-m sediment core from Rano Kau, Easter Island provides plant microfossil, arthropod fossil and high-resolution 14C sampling evidence for late Quaternary environments, ant (Formicidae) distributions and human ...
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Article
eIF5A isoforms and cancer: two brothers for two functions?
Eukaryotic translation initiation factor 5A (eIF5A) is the only cellular protein that contains the unusual amino acid hypusine [N ε-(4-amino-2-hydroxybutyl)lysine]. The role of hypusine formation ...
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Article
Open AccessErratum: Raf kinases mediate the phosphorylation of eukaryotic translation elongation factor 1A and regulate its stability in eukaryotic cells
Correction to: Cell Death and Disease (2012) 3, e276; doi:10.1038/cddis.2012.16; published online 1 March 2012 Since the publication of this article, the authors have noticed that the work was also performed b...
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Article
The implementation of international standardization of glycated hemoglobin. A “red-letter-day” for glycated hemoglobin in Italy: 1/1/11 Italian Recommendations of GLAD Working Group (A1c delegates WG)
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Article
Open AccessRaf kinases mediate the phosphorylation of eukaryotic translation elongation factor 1A and regulate its stability in eukaryotic cells
We identified eukaryotic translation elongation factor 1A (eEF1A) Raf-mediated phosphorylation sites and defined their role in the regulation of eEF1A half-life and of apoptosis of human cancer cells. Mass spe...
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Article
Systemin-inducible defence against pests is costly in tomato
The possible costs of inducible defences against pests were evaluated in tomato. To activate inducible resistance traits, we used transgenic plants that over-expressed the systemin precursor (prosystemin). The...
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Article
Open AccessOxidative stress and ERK1/2 phosphorylation as predictors of outcome in hepatocellular carcinoma patients treated with sorafenib plus octreotide LAR
We reported a relevant activity of the combination between sorafenib and octreotide long-acting release (LAR) in advanced hepatocellular carcinoma (HCC) patients. In this work, we have studied if oxidative str...
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Article
Open AccessGemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism
Gemcitabine (GEM, 2′,2′-difluorodeoxycytidine) is currently used in advanced pancreatic adenocarcinoma, with a response rate of < 20%. The purpose of our work was to improve GEM activity by addition of cannabi...
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Chapter
The Italian Electronic Public Administration Market Place: Small Firm Participation and Satisfaction
The paper reconstructs the path taken by the reform of public procurement in Italy which has gradually evolved from a and centralized market to an open and accessible one. Despite the development of the Electr...
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Article
Bioelectrical impedance phase angle in constitutionally lean females, ballet dancers and patients with anorexia nervosa
Several articles have described body composition in anorexia nervosa, whereas little is known about this issue in underweight ballet dancers and constitutionally lean females. The main aim of this study was to...
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Chapter and Conference Paper
Bioelectrical impedance phase angle as a predictor of survival in patients with advanced cancer
Bioelectrical impedance phase angle is a potentially sensible indicator of alterations in body composition due to malnutrition, frequent in advanced cancer patients. Malnutrition is characterized by changes in...
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Article
Anticancer drugs and hyperthermia enhance cytotoxicity induced by polyamine enzymatic oxidation products
A correlation between regulation of cell proliferation and polyamine metabolism is described. The latter can enter protein synthesis through the modification of eukaryotic initiation factor 5A (eIF5A) and the ...
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Article
C-Raf antagonizes apoptosis induced by IFN-α in human lung cancer cells by phosphorylation and increase of the intracellular content of elongation factor 1A
Interferon α (IFNα) induces both apoptosis and a counteracting epidermal growth factor Erk-dependent survival response in cancer cells. In this report, IFNα increased eukaryotic elongation factor 1A (eEF-1A) prot...
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Article
The biological functions of polyamine oxidation products by amine oxidases: Perspectives of clinical applications
The polyamines spermine, spermidine and putrescine are ubiquitous cell components. If they accumulate excessively within the cells, due either to very high extracellular concentrations or to deregulation of th...
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Article
The translation elongation factor 1A in tumorigenesis, signal transduction and apoptosis: Review article
An increasing number of evidences suggest the involvement of the eukaryotic elongation factor 1A, a core component of the protein synthesis machinery, at the onset of cell transformation. In fact, eEF1A is sho...
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Article
Translational and post-translational modifications of proteins as a new mechanism of action of Alpha-Interferon: Review article
Interferon-α (IFNα) is a recombinant protein widely used in the therapy of several neoplasms such as myeloma, renal cell carcinoma, epidermoid cervical and head and neck tumours and melanoma. IFNα, the first c...
