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  1. Article

    Open Access

    Minocycline for sporadic and hereditary cerebral amyloid angiopathy (BATMAN): study protocol for a placebo-controlled randomized double-blind trial

    Cerebral amyloid angiopathy (CAA) is a disease caused by the accumulation of the amyloid-beta protein and is a major cause of intracerebral hemorrhage (ICH) and vascular dementia in the elderly. The presence o...

    S. Voigt, E. A. Koemans, I. Rasing, E. S. van Etten, G. M. Terwindt, F. Baas in Trials (2023)

  2. Article

    Open Access

    The Personalized Parkinson Project: examining disease progression through broad biomarkers in early Parkinson’s disease

    Our understanding of the etiology, pathophysiology, phenotypic diversity, and progression of Parkinson’s disease has stagnated. Consequently, patients do not receive the best care, leading to unnecessary disab...

    B. R. Bloem, W. J. Marks Jr., A. L. Silva de Lima, M. L. Kuijf in BMC Neurology (2019)

  3. No Access

    Article

    Soluble TLR2 and 4 concentrations in cerebrospinal fluid in HIV/SIV-related neuropathological conditions

    HIV in the central nervous system (CNS) mainly infects microglial cells which are known to express toll-like receptors (TLRs). This paper aimed to study the role of soluble TLR2 (sTLR2), sTLR4, and other infla...

    Khutso M. Mothapo, J. ten Oever, P. Koopmans, F. F. Stelma in Journal of NeuroVirology (2017)

  4. No Access

    Article

    Ancillary investigations to diagnose parkinsonism: a prospective clinical study

    Various ancillary investigations can assist clinicians in the differential diagnosis of patients with parkinsonism. It is unknown which test offers greatest diagnostic value in clinical practice. We included 1...

    M. B. Aerts, R. A. J. Esselink, W. F. Abdo, F. J. A. Meijer in Journal of Neurology (2015)

  5. Article

    Structural biomarkers in the cerebrospinal fluid within 24 h after a traumatic spinal cord injury: a descriptive analysis of 16 subjects

    Prospective cohort study.

    M H Pouw, B K Kwon, M M Verbeek, P E Vos, A van Kampen, C G Fisher, J Street in Spinal Cord (2014)

  6. Article

    GLUT1 deficiency syndrome into adulthood: a follow-up study

    GLUT1 deficiency syndrome (GLUT1DS) is a treatable neurometabolic disorder in which glucose transport into the brain is disturbed. Besides the classic phenotype of intellectual disability, epilepsy, and moveme...

    W. G. Leen, M. Taher, M. M. Verbeek, E. J. Kamsteeg in Journal of Neurology (2014)

  7. Article

    Biomarkers in spinal cord injury

    Literature review.

    M H Pouw, A J F Hosman, J J van Middendorp, M M Verbeek, P E Vos in Spinal Cord (2009)

  8. No Access

    Article

    1st Conference Clinical Trials on Alzheimer’s Disease September 17-18-19, 2008 School of Medecine Montpellier, France

    A. Gabelle, S. Roche, C. Gény, F. Portet in The Journal of Nutrition Health and Aging (2008)

  9. No Access

    Article

    Meningoencephalitis caused by Streptococcus pneumoniae: a diagnostic and therapeutic challenge

    Streptococcus pneumoniae is a common cause of bacterial meningitis but only rarely causes other infections such as brain abscess, encephalitis, encephalomyelitis or meningoencephalitis. We report on three adult p...

    Philippe G. Jorens, Paul M. Parizel, Hendrik E. Demey, Katrien Smets in Neuroradiology (2005)

  10. No Access

    Article

    glut1-deficiëntie: een diagnose die makkelijk gemist wordt

    glut1 (glucose transport protein type 1) deficiency syndrome causes reduced blood brain barrier glucose transport. The most important factor in laboratory tests is low glucose concentration in csf. In a retrospec...

    M. E. Pouwels, M. A. A. P. Willemsen, M. M. Verbeek in Tijdschrift voor kindergeneeskunde (2004)

  11. No Access

    Article

    Serum- and CSF-concentrations of brain specific proteins in hydrocephalus

    T. Beems, K. S. Simons, W. J. A. van Geel, H. P. M. de Reus in Acta Neurochirurgica (2003)

  12. No Access

    Article

    Distribution of Aβ-associated proteins in cerebrovascular amyloid of Alzheimer’s disease

    Senile plaques and cerebrovascular amyloidosis (CA) are two of the major neuropathological lesions in brains of patients with dementia of the Alzheimer type. We studied the expression of a number of amyloid β...

    M. M. Verbeek, Irene Otte-Höller, Robert Veerhuis, Dirk J. Ruiter in Acta Neuropathologica (1998)

  13. No Access

    Article

    Differential expression of intercellular adhesion molecule-1 (ICAM-1) in the A-containing lesions in brains of patients with dementia of the Alzheimer type

    Inflammatory processes have been implicated in the formation of senile plaques in the cerebral cortex of patients with dementia of the Alzheimer type (DAT), since several inflammation-induced proteins are pre...

    M. M. Verbeek, Irene Otte-Höller, Pieter Wesseling, Dirk J. Ruiter in Acta Neuropathologica (1996)

  14. No Access

    Article

    A lysosomal marker for activated microglial cells involved in Alzheimer classic senile plaques

    One of the major histopathological lesions in brains of patients with dementia of the Alzheimer type (DAT) is the senile plaque. Although previous studies have shown that senile plaques are often accompanied b...

    M. M. Verbeek, I. Otte-Höller, P. Wesseling, W. E. Van Nostrand in Acta Neuropathologica (1995)