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Article
Open AccessMinocycline for sporadic and hereditary cerebral amyloid angiopathy (BATMAN): study protocol for a placebo-controlled randomized double-blind trial
Cerebral amyloid angiopathy (CAA) is a disease caused by the accumulation of the amyloid-beta protein and is a major cause of intracerebral hemorrhage (ICH) and vascular dementia in the elderly. The presence o...
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Article
Open AccessThe Personalized Parkinson Project: examining disease progression through broad biomarkers in early Parkinson’s disease
Our understanding of the etiology, pathophysiology, phenotypic diversity, and progression of Parkinson’s disease has stagnated. Consequently, patients do not receive the best care, leading to unnecessary disab...
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Article
Soluble TLR2 and 4 concentrations in cerebrospinal fluid in HIV/SIV-related neuropathological conditions
HIV in the central nervous system (CNS) mainly infects microglial cells which are known to express toll-like receptors (TLRs). This paper aimed to study the role of soluble TLR2 (sTLR2), sTLR4, and other infla...
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Article
Ancillary investigations to diagnose parkinsonism: a prospective clinical study
Various ancillary investigations can assist clinicians in the differential diagnosis of patients with parkinsonism. It is unknown which test offers greatest diagnostic value in clinical practice. We included 1...
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Article
Structural biomarkers in the cerebrospinal fluid within 24 h after a traumatic spinal cord injury: a descriptive analysis of 16 subjects
Prospective cohort study.
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Article
GLUT1 deficiency syndrome into adulthood: a follow-up study
GLUT1 deficiency syndrome (GLUT1DS) is a treatable neurometabolic disorder in which glucose transport into the brain is disturbed. Besides the classic phenotype of intellectual disability, epilepsy, and moveme...
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Article
Biomarkers in spinal cord injury
Literature review.
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Article
1st Conference Clinical Trials on Alzheimer’s Disease September 17-18-19, 2008 School of Medecine Montpellier, France
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Article
Meningoencephalitis caused by Streptococcus pneumoniae: a diagnostic and therapeutic challenge
Streptococcus pneumoniae is a common cause of bacterial meningitis but only rarely causes other infections such as brain abscess, encephalitis, encephalomyelitis or meningoencephalitis. We report on three adult p...
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Article
glut1-deficiëntie: een diagnose die makkelijk gemist wordt
glut1 (glucose transport protein type 1) deficiency syndrome causes reduced blood brain barrier glucose transport. The most important factor in laboratory tests is low glucose concentration in csf. In a retrospec...
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Article
Serum- and CSF-concentrations of brain specific proteins in hydrocephalus
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Article
Distribution of Aβ-associated proteins in cerebrovascular amyloid of Alzheimer’s disease
Senile plaques and cerebrovascular amyloidosis (CA) are two of the major neuropathological lesions in brains of patients with dementia of the Alzheimer type. We studied the expression of a number of amyloid β...
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Article
Differential expression of intercellular adhesion molecule-1 (ICAM-1) in the A‚-containing lesions in brains of patients with dementia of the Alzheimer type
Inflammatory processes have been implicated in the formation of senile plaques in the cerebral cortex of patients with dementia of the Alzheimer type (DAT), since several inflammation-induced proteins are pre...
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Article
A lysosomal marker for activated microglial cells involved in Alzheimer classic senile plaques
One of the major histopathological lesions in brains of patients with dementia of the Alzheimer type (DAT) is the senile plaque. Although previous studies have shown that senile plaques are often accompanied b...