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Chapter and Conference Paper
Measuring the Time Impact of Web Accessibility Barriers on Blind Users: A Pilot Study
As governments around the world increase or clarify the requirements related to web accessibility for public accommodations, they often require some level of cost-benefit analysis for the proposed regulation....
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Article
How do I manage hyperglycemia/post-transplant diabetes mellitus after allogeneic HSCT
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients frequently develop glucose intolerance and post-transplant diabetes mellitus (PTDM). The clinical importance of PTDM and its detrimenta...
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Article
Open AccessA genomic analysis of Philadelphia chromosome-negative AML arising in patients with CML
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Article
U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing
We previously identified missense mutations in the U2AF1 splicing factor affecting codons S34 (S34F and S34Y) or Q157 (Q157R and Q157P) in 11% of the patients with de novo myelodysplastic syndrome (MDS). Although...
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Article
Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer
The drug fluorouracil (5-FU) is a widely used antimetabolite chemotherapy in the treatment of colorectal cancer. The gene uridine monophosphate synthetase (UMPS) is thought to be primarily responsible for convers...
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Article
Artificial corneas: a regenerative medicine approach
Corneal substitutes are being developed to address the shortage of human donor tissues as well as the current disadvantages in some clinical indications, which include immune rejection. In the past few years, ...
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Article
Expressed sequence tags from the Yukon ecotype of Thellungiella reveal that gene expression in response to cold, drought and salinity shows little overlap
Thellungiella salsuginea (also known as T. halophila) is a close relative of Arabidopsis that is very tolerant of drought, freezing, and salinity and may be an appropriate model to identify the molecular mechanis...
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Chapter and Conference Paper
The Development and Optimisation of High Bandwidth Bimorph Deformable Mirrors
Our first mirror designs were based on a standard bimorph construction and exhibited a resonant frequency of 1 kHz with a maximum stroke of ±5 μm. These devices were limited by the requirement to have a “dead ...
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Article
Open AccessTrends in mortality for cancers, comparing multiple- and underlying-cause rates, in an English population 1979–1999
In compiling official mortality statistics, rules for selecting the underlying cause of death have changed twice in the last 20 years in England. Mortality statistics for most types of cancer were not greatly ...
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Article
Open AccessChildhood cancer incidence in a cohort of twin babies
We studied childhood cancer incidence in a population-based twin cohort using record linkage to the National Registry of Childhood Tumours. After correcting for mortality, an incidence deficit was observed (St...
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Article
Genetic studies of antifreeze proteins and their correlation with winter survival in wheat
Antifreeze proteins (AFPs) accumulate in the leaves of winter cereals during cold acclimation, where they may inhibit ice recrystallization during freezing and thawing cycles and provide nonspecific disease re...
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Chapter and Conference Paper
Calibration Issues in the Search for Large-Scale Anisotropies in the 87 Green Bank and Parkes-Mit-Nrao Surveys
Until recently, there were no large scale radio surveys which were sensitive enough to have a sufficient number of sources to detect a dipole anisotropy. The 87 Green Bank (87GB) (Gregory and Condon, 1991) and...
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Chapter
Characterization of Antifreeze Proteins from Winter Rye
When winter settles upon the landscape and the soil and lakes have frozen, it is important to realize that many biological organisms have frozen too. After a period of acclimatization to cold autumn temperatur...
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Article
Immunogold localization of glucanase-like antifreeze protein in cold acclimated winter rye
Apoplastic antifreeze proteins (AFPs) accumulate in winter rye (Secale cereale L. cv. Musketeer) leaves during cold acclimation. Two of the rye AFPs with molecular masses of 32 and 35 kDa are similar in their ami...
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Chapter
Vegetative Development
Arabidopsis thaliana is a rosette annual with separate vegetative and reproductive growth phases. Vegetative development is characterized by the production of rosette leaves in a phyllotactic spiral with little ...
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Article
Ultrapure plasma factor VIII produced by anti-FVIIIc immunoaffinity chromatography and solvent/detergent viral inactivation. Characterization of the Method M process and Hemofil M antihemophilic factor (human)
The Method M process was developed to reduce the risk of virus transmission associated with the therapeutic use of AHF products. The Method M process uses a powerful viral inactivation approach and consistentl...
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Article
In-process controls and characterization of recombinate antihemophilic factor (recombinant)
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Article
Functional xylem anatomy in root-shoot junctions of six cereal species
In cereals, the formation of safety zones in the root-shoot junction could protect the vessels of roots from embolism originating in the shoot. The root-shoot junction was examined both anatomically, with a li...
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Article
Phytoplankton community structure and distribution in the nearshore zone of Lake Ontario
Spatial and temporal distributions of phytoplankton were studied during 1979 in the nearshore zone of Lake Ontario. Genera such as Dinobryon, Oscillatoria, and Gymnodinium tended to be found at discrete depths wh...
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Chapter
The Effects of Low Temperature growth on the Structure of Photosystem II
When thylakoids are isolated from winter rye grown at 5°C, they exhibit higher PSII activities over the temperature range 8–26°C than thylakoids isolated from plants grown at 20°C (Huner, Hopkins, unpublished). H...