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Article
Modeling the Mechanisms by Which Coexisting Biomolecular RNA–Protein Condensates Form
Liquid–liquid phase separation is an emerging mechanism for intracellular organization. This work presents a mathematical model to examine molecular mechanisms that yield phase-separated droplets composed of d...
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Article
Nonfocusing Instabilities in Coupled, Integrable Nonlinear Schrödinger pdes
instabilities that exist independently of the well-known modulational instability of the focusing NLS equation. The focusing versus defocusing behavior of scalar NLS fields is a well-known model for the corre...
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Article
Onset of Oscillations in Nonsoliton Pulses in Nonlinear Dispersive Fibers
We study the modulation equations for the amplitude and phase of smoothed rectangular pulse initial data for the defocusing nonlinear Schrodinger (NLS) equation in the semiclassical limit, and show that these...
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Article
La puberté surrénalienne
La surrénale produit surtout des stéroïdes de la voie Δ5, la déhydroépiandrostérone (DHA) et son sulfate (DHAS). Leurs taux très élvés à la naissance, décroissent rapidement les premiers mois de vie, et sont très...
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Article
Strongly nonlinear modal equations for nearly integrable PDEs
The purpose of this paper is the derivation of reduced, finite-dimensional dynamical systems that govern the near-integrable modulations ofN-phase, spatially periodic, integrable wavetrains. The small parameter i...
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Article
ADRENARCHE IN PATIENTS WITH CONGENITAL ADRENAL HYPERPLASIA (CAH) DUE TO 21-HYDROXYLASE DEFICIENCY
In order to evaluate adrenarche in female patients with CAH, plasma concentrations of dehydroepiandrosterone sulfate (DHEAS) were determined (by a specific RIA) longitudinally from 4 to 11 years of age in 16 C...
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Article
PRENATAL TREATMENT OF CONGENITAL ADRENAL HYPERPLASIA (CAH) DUE TO 21-HYDROXYLASE DEFICIENCY: EUROPEAN EXPERIENCE IN 223 PREGNANCIES AT RISK
In the aim to prevent the in utero virilization of CAH affected females a prenatal treatment (Rx) has first been attempted by David and Forest in 1979; later these authors reported their first results and propose...
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Article
PRENATAL DIAGNOSIS OF CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY
Prenatal diagnosis of the classic forms of the congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency has progressed at the same time as the advances made in the field of both endocrinology and ...
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Chapter and Conference Paper
Modulation Equations for Nearly Integrable PDEs with Periodic Boundary Conditions
This note, following my lecture, is a summary of the current state of practical application of periodic, N-phase modulation equations. First, I sketched interesting bifurcation phenomena that have been documen...
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Chapter
Application of the Bäcklund-Transformation in the Sine-Gordon System
In recent years the spectral transform for the sine-Gordon equation has been carefully investigated [1–3]. At the same time the perturbed sine-Gordon system has been used as a model for long Josephson tunnel j...
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Article
Prenatal treatment of congenital adrenal hyperplasia: Report of a new case
A mother at risk for 21-hydroxylase deficiency was treated with oral dexamethasone (0.5 mg 12 hourly) from early pregnancy, in an attempt to prevent in utero virilization in case of a female fetus. Fetal karyo...
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Article
124 IN VIVO AND IN VITRO STUDIES OF A JUVENILE GRANULOSA CELL TUMOR
A 16 month-old girl was seen for precocious puberty (breast, pubic hair). Plasma levels (ng/dl) of progesterone (P) (574-1830), 17OH-progesterone (OHP) (181-195) and estradiol (E2) (23-40) were in the range of an...
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Article
9 CRYPTORCHIDISM: COMPARISON OF 2 PROTOCOLS OF TREATMENT BY HUMAN CHORIONIC CONADOTROPIN (hCG)
It is Deneved that the positive action of hCG on cryptorchidism is mediated by the rise in endogenous testosterone (T). Previous studies have shown that plasma T rises steadily for 4-5 days (d.) after a single...
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Article
Partial 17, 20-desmolase and 17α-hydroxylase deficiencies in a 16-year-old boy
Thirteen plasma steroids as well as ACTH, LH and FSH were measured by specific RIAs under basal and dynamic conditions in a 16-year-old boy (normal external genitalia, 46, XY karyotype) who presented slowness ...
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Article
SEX STEROID BINDING PROTEIN (SBP) IN PREMATURE INFANTS
We have recently reported that SBP is measurable in amniotic fuid: low levels with no sex difference, but showing a significant (p=0.02) correlation (r=0.587) with gestational age (GA). This prompted us to exa...
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Article
DEVELOPMENTAL PATTERN OF PLASMA SEX STEROID BINDING PROTEIN (SBP) IN THE ANDROGEN INSENSITIVITY SYNDROME (AIS): PUBERTAL CHANGES INDEPENDENT OF SEX STEROIDS ?
SBP was measured by a solid phase method in 80 plasma samples from 24 AIS subjects 1 mo-17 yr old. Results (μg/l) were compared to those found in 375 normal males matched for age. Weight was normal for height ...
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Article
SEX HORMONE BINDING PROTEIN (SBP) AS A MARKEh OF ANDROGEN SENSITIVITY IN INFANTS AND CHILDREN
Establishing a reliable test of androgen sensitivity is still prerequisite for etiological diagnosis in infants suspected of androgen insensitivity syndrome (AIS). Since androgens are known to decrease SBP lev...
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Article
BIOACTIVE LUTEOTROPIN (LH) IN URINE: NYCTHEMERAL VARIATION IN BIOLOGICAL POTENCY IN MID-PUBERTY
A previous work (Arch.Fr.Pediatr. 1985,42, 579) has shown the usefulness of immunoassayabled (I) urinary LH levels for assessing gonadotropic function in children and adolescents. To further investigate the physi...
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Article
123 LATE ONSET 21-OH-DEFICIENCY (21-OHD) CAN BE MISDIAGNOSED AS “TYPICAL PREMATURE PUBARCHE” (PP) IN CHILDHOOD
The isolated and early growth of pubic hair (PH) is often associated with slight advance in bone age (BA) and statural age (SA). Diagnosis of PP is classically made on high levels of dehydroepiandrosterone sul...
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Article
124 PRENATAL DIAGNOSIS OF 17-KETOSTEROID REDUCTASE DEFICIENCY
In the index case, first child of the family, diagnosis of 17-ketosteroid reductase deficiency(17-KSRD) was made at 3 months of age on the response of testosterone(T) and Δ4-androstenedone(Δ4) after an hCG test :...
