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Article
Open AccessA mechanistic approach to weighting edge-effects in landscape connectivity assessments
Understanding landscape functional connectivity is critical for nature conservation in fragmented landscapes. Spatially explicit graph-theoretical approaches to assessing landscape connectivity have provided a...
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Article
Open AccessThe considerations, experiences and support needs of family members making treatment decisions for patients admitted with major stroke: a qualitative study
Treatment decision-making by family members on behalf of patients with major stroke can be challenging because of the shock of the diagnosis and lack of knowledge of the patient’s treatment preferences. We aim...
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Article
Characterization of a Laser Extensometer for Split Hopkinson Pressure bar Experiments
This paper examines a laser extensometer to calculate the strain in a sample during split Hopkinson pressure bar (SHPB) experiments. This method offers a non-contact, direct method for measuring sample strain ...
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Article
Open AccessA comparison of clofarabine with ara-C, each in combination with daunorubicin as induction treatment in older patients with acute myeloid leukaemia
The study was designed to compare clofarabine plus daunorubicin vs daunorubicin/ara-C in older patients with acute myeloid leukaemia (AML) or high-risk myelodysplastic syndrome (MDS). Eight hundred and six unt...
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Article
Open AccessProceedings of the First International Conference on Stepped Wedge Trial Design
I1 Introduction
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Article
No association between RORA polymorphisms and PTSD in two independent samples
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Article
EBV-associated post-transplant lymphoproliferative disorder following in vivo T-cell-depleted allogeneic transplantation: clinical features, viral load correlates and prognostic factors in the rituximab era
EBV-associated post-transplant lymphoproliferative disease (PTLD) following Alemtuzumab-based allo-SCT is a relatively uncommon and challenging clinical problem but has not received detailed study in a large c...
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Article
Open AccessApricoxib upregulates 15-PGDH and PGT in tobacco-related epithelial malignancies
Despite focused research in conventional therapies and considerable advances in the understanding of the molecular carcinogenesis of head and neck squamous cell carcinoma (HNSCC), the 5-year survival rate for ...
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Article
Upper limb motor function in young adults with spina bifida and hydrocephalus
The objective of the study was to measure upper limb motor function in young adults with spina bifida meningomyelocele (SBM) and typically develo** age peers.
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Article
A practical assessment of magnetic resonance diffusion-perfusion mismatch in acute stroke: observer variation and outcome
MR diffusion/perfusion mismatch may help identify patients for acute stroke treatment, but mixed results from clinical trials suggest that further evaluation of the mismatch concept is required. To work effect...
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Article
Linkage disequilibrium structure of KIAA0319 and DCDC2, two candidate susceptibility genes for developmental dyslexia
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Article
Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia
The DYX2 locus on chromosome 6p22.2 is the most replicated region of linkage to developmental dyslexia (DD). Two candidate genes within this region have recently been implicated in the disorder: KIAA0319 and DCDC...
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Article
Functional outcome in young adults with spina bifida and hydrocephalus
Quality of life was studied in 31 adult survivors of spina bifida, each with Verbal or Performance IQ score over 70.
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Article
Reply to “SIV and HIV prophylaxis”
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Article
Relief of spasticity in SCI men and women using rectal probe electrostimulation
Although there are numerous approaches to the treatment of spasticity, many patients are still unable to find a satisfactory method of managing their spasms with acceptable side effects. In the course of our f...
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Article
Computed tomography in patients with transient ischaemic attacks: when is a transient ischaemic attack not a transient ischaemic attack but a stroke?
In a prospective community-based study, 184 patients with transient ischaemic attacks (TIAs) were identified from a study population of about 105,000 between 1981 and 1986. Computed tomography (CT) was attempt...
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Chapter
Topographical Analysis of the Torpedo Marmorata Acetylcholine Receptor by Energy Transfer Photoaffinity Labeling Using Aryldiazonium Derivatives
The acetylcholine and the non competitive blockers binding sites of the native, membrane-bound acetylcholine receptor from Torpedo Marmorata were covalently photo-labeled by aryldiazonium derivatives.These der...
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Chapter
Allosteric Sites and Conformational Transitions of the Acetylcholine Receptor: Models for Short-term Regulation of Receptor Response
The word “receptor” is commonly used with two separate significations: for the site complementary to the structure of the chemical messenger and for the protein which carries the site. From a functional point of ...
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Chapter
Allosteric Sites and Conformational Transitions of the Acetylcholine Receptor: Models for Short-term Regulation of Receptor Response
The word “receptor” is commonly used with two separate significations: for the site complementary to the structure of the chemical messenger and for the protein which carries the site. From a functional point of ...
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Chapter and Conference Paper
Tertiary Structure of the Nicotinic Acetylcholine Receptor Probed by Photolabeling and Protein Chemistry
The nicotinic Ach-receptor in vertebrates consists of four subunits assembled into an heterologous α2βγδ pentamer. The cDNAs coding for the constitutive four chains of the Ach-receptor have been cloned and sequen...
