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  1. Article

    Open Access

    Overexpression of human kynurenine-3-monooxygenase protects against 3-hydroxykynurenine-mediated apoptosis through bidirectional nonlinear feedback

    Kynurenine 3-monooxygenase (KMO) is a critical regulator of inflammation. The preferred KMO substrate, kynurenine, is converted to 3-hydroxykynurenine (3HK), and this product exhibits cytotoxicity through mech...

    K Wilson, M Auer, M Binnie, X Zheng, N T Pham, J P Iredale in Cell Death & Disease (2016)