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Article
Open AccessPro-poor policies and improvements in maternal health outcomes in India
Since 2005, India has experienced an impressive 77% reduction in maternal mortality compared to the global average of 43%. What explains this impressive performance in terms of reduction in maternal mortality ...
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Article
Application of nanoadsorbents for removal of lead from water
Enormous increase in the application of various heavy metals including lead for commercial and non-commercial purposes has also led to their enhanced occurrence in the effluents from industries and domestic di...
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Article
Cystathionine-γ-lyase gene silencing with siRNA in monocytes/macrophages attenuates inflammation in cecal ligation and puncture-induced sepsis in the mouse
Hydrogen sulphide is an endogenous inflammatory mediator produced by cystathionine-γ-lyase (CSE) in macrophages. To determine the role of H2S and macrophages in sepsis, we used small interference RNA (siRNA) to t...
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Article
The safety and feasibility of probiotics in children and adolescents undergoing hematopoietic cell transplantation
Hematopoietic cell transplantation (HCT) has become a standard treatment for many adult and pediatric conditions. Emerging evidence suggests that perturbations in the microbiota diversity increase recipients’ ...
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Chapter
Effect of Substituted Aluminum in Magnesium Tension Twin
Atomistic simulations are performed in order to study the Aluminum substitution effect on Magnesium twinning mechanism. Multiple twin boundaries are found in pure Mg single crystal under tensile loading condit...
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Chapter
Effect of Substituted Aluminum in Magnesium Tension Twin
Atomistic simulations are performed in order to study the Aluminum substitution effect on Magnesium twinning mechanism. Multiple twin boundaries are found in pure Mg single crystal under tensile loading condit...
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Article
Cystathionine-gamma-lyase gene silencing with siRNA in monocytes/macrophages protects mice against acute pancreatitis
Hydrogen sulphide (H2S) is an endogenous inflammatory mediator produced by cystathionine-γ-lyase (CSE) in monocytes/macrophages. To determine the role of H2S and macrophages in inflammation, we used small interfe...
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Article
Sequential myeloablative autologous stem cell transplantation and reduced intensity allogeneic hematopoietic cell transplantation is safe and feasible in children, adolescents and young adults with poor-risk refractory or recurrent Hodgkin and non-Hodgkin lymphoma
The outcome of children, adolescents and young adults (CAYA) with poor-risk recurrent/refractory lymphoma is dismal (⩽30%). To overcome this poor prognosis, we designed an approach to maximize an allogeneic gr...
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Article
Reduced toxicity, myeloablative conditioning with BU, fludarabine, alemtuzumab and SCT from sibling donors in children with sickle cell disease
BU and CY (BU/CY; 200 mg/kg) before HLA-matched sibling allo-SCT in children with sickle cell disease (SCD) is associated with ~85% EFS but is limited by the acute and late effects of BU/CY myeloablative condi...
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Article
Plasma citrulline as a biomarker for enterocyte integrity in pediatric blood and BMT
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Article
The pharmacokinetics and safety of twice daily i.v. BU during conditioning in pediatric allo-SCT recipients
Intravenous BU divided four times daily (q6 h) has been shown to be safe and effective in pediatric allo-SCT recipients. Though less frequent dosing is desirable, pharmacokinetic (PK) data on twice daily (q12 ...
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Article
Evidence for the transmission of neoplastic properties from transformed to normal human stem cells
The in vivo relationship between human tumor cells and interacting normal cells in their local environment is poorly understood. Here, using a uniquely developed in vitro co-culture system for human embryonic ste...
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Article
A pilot study of reduced toxicity conditioning with BU, fludarabine and alemtuzumab before the allogeneic hematopoietic SCT in children and adolescents
We report the results of a pilot study of a BU–fludarabine–alemtuzumab (BFA)-reduced toxicity conditioning (RTC) followed by allogeneic hematopoietic SCT (AlloHSCT) in 12 children and adolescents (<21 years) w...
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Article
Pericardial effusion post-SCT in pediatric recipients with signs and/or symptoms of cardiac disease
The objective of this study was to assess the incidence, risk factors, outcome and impact on OS of pericardial effusion (PEF) in a cohort of 156 pediatric SCT recipients. The mean age was 8.15±6.25 years. In a...
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Article
Treatment with bindarit, an inhibitor of MCP-1 synthesis, protects mice against trinitrobenzene sulfonic acid-induced colitis
Chemokines play a fundamental role in trafficking and activation of leukocytes in colonic inflammation. We investigated the ability of bindarit, an inhibitor of monocyte chemoattractant protein-1 (MCP-1/CCL2) ...
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Article
Hematopoietic cell transplantation for thalassemia and sickle cell disease: past, present and future
β-Thalassemia major and sickle cell disease (SCD) are among the most common hereditary disorders worldwide. The supportive treatment of β-thalassemia major requires chronic, life-long RBC transfusions, which c...
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Article
Reduced intensity allogeneic umbilical cord blood transplantation in children and adolescent recipients with malignant and non-malignant diseases
There is a significant amount of morbidity and mortality following myeloablative umbilical cord blood transplantation (UCBT). Reduced intensity (RI) conditioning offers an alternative to myeloablative conditio...
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Article
Flurbiprofen and its nitric oxide-releasing derivative protect against septic shock in rats
Flurbiprofen and nitroflurbiprofen were evaluated in a caecal ligation puncture (CLP) model of septic shock in the rat.
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Article
Undetectable leukemic blasts and absence of NOD/SCID leukemia-initiating cells in cord blood from a case of maternal AML
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Article
Hematopoietic capacity of adult human skeletal muscle is negligible
Using experimental mouse models, hematopoietic potential has been shown to exist within skeletal muscle. In humans, the clinical utility of using muscle-derived hematopoietic progenitors remains uncertain. Her...
