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  1. Article

    Open Access

    Circulating biosignatures in multiple myeloma and their role in multidrug resistance

    A major obstacle to chemotherapeutic success in cancer treatment is the development of drug resistance. This occurs when a tumour fails to reduce in size after treatment or when there is clinical relapse after...

    S. Rajeev Krishnan, M. Bebawy in Molecular Cancer (2023)

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  2. No Access

    Article

    Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells

    Multidrug resistance (MDR), a significant impediment to the successful treatment of cancer clinically, has been attributed to the overexpression of P-glycoprotein (P-gp), a plasma membrane multidrug efflux tra...

    M Bebawy, V Combes, E Lee, R Jaiswal, J Gong, A Bonhoure, G E R Grau in Leukemia (2009)

  3. Article

    Open Access

    Selective modulation of P-glycoprotein-mediated drug resistance

    Multidrug resistance associated with the overexpression of the multidrug transporter P-glycoprotein is a serious impediment to successful cancer treatment. We found that verapamil reversed resistance of CEM/VLB10...

    M Bebawy, M B Morris, B D Roufogalis in British Journal of Cancer (2001)

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