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Article
Open AccessAdvancing Biomarker Development Through Convergent Engagement: Summary Report of the 2nd International Danube Symposium on Biomarker Development, Molecular Imaging and Applied Diagnostics; March 14–16, 2018; Vienna, Austria
Here, we report on the outcome of the 2nd International Danube Symposium on advanced biomarker development that was held in Vienna, Austria, in early 2018. During the meeting, cross-speciality participants ass...
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Article
High incidence of Philadelphia chromosome-like acute lymphoblastic leukemia in older adults with B-ALL
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Article
NPM-ALK phosphorylates WASp Y102 and contributes to oncogenesis of anaplastic large cell lymphoma
Mechanisms by which NPM-ALK signaling regulates cell migration, invasion and contributes to the oncogenesis of anaplastic large cell lymphoma (ALCL) are not completely understood. In an attempt to identify nov...
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Article
Novel ALK fusion in anaplastic large cell lymphoma involving EEF1G, a subunit of the eukaryotic elongation factor-1 complex
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Article
Effects of Melatonin on Colchicine-Treated PLBs of Dendrobium sonia-28 Orchid
Dendrobium hybrid orchid is popular in orchid commercial industry due to its short life cycle and ability to produce various types of flower colours. This study was conducted to identify ...
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Article
Oncogenic Y641 mutations in EZH2 prevent Jak2/β-TrCP-mediated degradation
EZH2 (enhancer of zeste homolog 2) is a critical enzymatic subunit of the polycomb repressive complex 2 (PRC2), which trimethylates histone H3 (H3K27) to mediate gene repression. Somatic mutations, overexpress...
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Article
Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival
Prostate apoptosis response protein 4 (Par-4) also known as PRKC apoptosis WT1 regulator is a tumor suppressor that selectively induces apoptosis in cancer cells. However, its post-translational regulation by ...
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Article
Open AccessThe role of front-line anthracycline-containing chemotherapy regimens in peripheral T-cell lymphomas
Peripheral T-cell lymphomas (PTCLs) are a heterogenous group of aggressive non-Hodgkin’s lymphomas that are incurable in the majority of patients with current therapies. Outcomes associated with anthracycline-...
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Article
NPM-ALK signals through glycogen synthase kinase 3β to promote oncogenesis
Anaplastic large cell lymphoma (ALCL) is the most common type of pediatric peripheral T-cell lymphoma. In 70–80% of cases, the chromosomal aberration t(2;5)(p23;q35) results in the juxtaposition of anaplastic lym...
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Article
A Novel Lateral Field Emission Triode for Microwave Application
We propose a novel lateral field emission triode, which does not require any additional vacuum sealing process and exhibits superb field emitter triode performance. The purpose of this paper is to compare tita...
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Article
The dual PI3K/mTOR inhibitor, NVP-BEZ235, is efficacious against follicular lymphoma
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Article
Loss of Ubr1 promotes aneuploidy and accelerates B-cell lymphomagenesis in TLX1/HOX11-transgenic mice
The TLX1/HOX11 homeobox gene was originally identified at the recurrent t(10;14)(q24;q11) translocation breakpoint, a chromosomal abnormality observed in 5–7% of T-cell acute lymphoblastic leukemias (T-ALLs). Pro...
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Article
Dysregulated expression of mitotic regulators is associated with B-cell lymphomagenesis in HOX11-transgenic mice
Dysregulated expression of the homeobox gene, HOX11 is a frequent etiologic event in T-cell acute lymphoblastic leukemias. HOX11-transgenic mice (IgHμ-HOX11Tg)-expressing HOX11 in the B-cell compartment develop B...
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Article
Microstructural and mechanical stability of Cu-6 wt. % Ag alloy
The microstructural and mechanical stability of Cu-6 wt. % Ag alloy obtained by cold rolling combined with intermediate heat treatments have been investigated. The stress-strain responses and fracture behavior...
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Article
Polycrystalline Silicon Single Electron Island by Excimer Laser Irradiation on a-Si Film
We propose a novel fabrication method for a room temperature operating single-electron memory using the size and location controlled poly-Si island by lithographic technique and excimer laser annealing.
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Chapter
Real-Time Implementation of QCELP Vocoder for speech and data in CDMA Cellular System Using TMS320C50 Fixed Point DSP Chip
An variable rate QCELP speech coder was proposed for CDMA digital cellular system and QCELP algorithm has been chosen as the speech coder of digital cellular system in North America and Korea. ...
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Chapter and Conference Paper
Thin Filament-Linked Regulation in Vertebrate Smooth Muscle
It is widely accepted that myosin-linked regulation, specifically the reversible phosphorylation of myosin, represents the primary Ca2+-dependent mechanism for the regulation of smooth muscle contraction. This me...