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Article
Open AccessEvaluating the necessity of PCR duplicate removal from next-generation sequencing data and a comparison of approaches
Analyzing next-generation sequencing data is difficult because datasets are large, second generation sequencing platforms have high error rates, and because each position in the target genome (exome, transcrip...
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Article
Open AccessVariants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels
Prostatic Acid Phosphatase (PAP) is an enzyme that is produced primarily in the prostate and functions as a cell growth regulator and potential tumor suppressor. Understanding the genetic regulation of this en...
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Article
Open AccessGenome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid
Prolactin is a polypeptide hormone secreted by the anterior pituitary gland that plays an essential role in lactation, tissue growth, and suppressing apoptosis to increase cell survival. Prolactin serves as a ...
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Article
Open AccessVariants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels
CCL16 is a chemokine predominantly expressed in the liver, but is also found in the blood and brain, and is known to play important roles in immune response and angiogenesis. Little is...