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Article
Continuous sheathless particle separation in viscoelastic fluids with different rheological properties
The separation of particles such as cells and bacteria in viscoelastic fluids has significant applications in biomedical fields. At present, one of the main challenges that limit the application of microfluidi...
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Article
Open AccessA novel mutation of CTC1 leads to telomere shortening in a chinese family with interstitial lung disease
Interstitial lung diseases (ILDs), or diffuse pulmonary lung disease, are a subset of lung diseases that primarily affect lung alveoli and the space around interstitial tissue and bronchioles. It clinically ma...
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Article
Fatigue Failure Analysis of Spring Coupling Diaphragm in Wind Power Generator
Premature failure of the spring diaphragm of coupling in wind power generator has been frequently reported. The cause of the failure spring diaphragm was analyzed by chemical composition, mechanical property, ...
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Article
Naringenin alleviates bone cancer pain in rats via down-regulating spinal P2X7R /PI3K/AKT signaling: involving suppression in spinal inflammation
Bone cancer pain (BCP) seriously affects patient’s quality of life, which remains a difficult clinical problem, lacking effective drugs for treating it. The inflammation in the spinal cord involves the pathoge...
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Article
Bi-allelic BRWD1 variants cause male infertility with asthenoteratozoospermia and likely primary ciliary dyskinesia
Genetics-associated asthenoteratozoospermia is often seen in patients with multiple morphological abnormalities of the sperm flagella (MMAF). Although 24 causative genes have been identified, these explain onl...
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Article
Open AccessIdentification of a novel mutation of NOG in family with proximal symphalangism and early genetic counseling
Proximal symphalangism is a rare disease with multiple phenotypes including reduced proximal interphalangeal joint space, symphalangism of the 4th and/or 5th finger, as well as hearing loss. At present, at lea...
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Article
A De Novo Novel Nonsense Mutation of GATA4 is Responsible for a Patient with Atrial Septal Defect
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Article
Open AccessAn effective combination of whole-exome sequencing and runs of homozygosity for the diagnosis of primary ciliary dyskinesia in consanguineous families
Primary ciliary dyskinesia (PCD) is clinically characterized by neonatal respiratory distress, chronic sinusitis, bronchiectasis and infertility, and situs inversus in 50% of the patients. PCD is a result of m...
