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  1. Article

    Open Access

    Effect of P53 nuclear localization mediated by G3BP1 on ferroptosis in acute liver failure

    This study investigated whether G3BP1 could regulate ferroptosis in hepatocytes during ALF by affecting the entry of P53 into the nucleus. Promoting G3BP1 expression could inhibit P53 entry by binding to the n...

    Wenyuan Li, Wei Li, Xun Li, Luwen Wang, Yao Wang in Apoptosis (2023)

  2. Article

    Open Access

    Histone deacetylase 2 regulates ULK1 mediated pyroptosis during acute liver failure by the K68 acetylation site

    Pyroptosis is a new necrosis pattern of hepatocyte during liver inflammation in acute liver failure (ALF). Histone deacetylase 2 (HDAC2) is associated with several pathological conditions in the liver system. ...

    Yao Wang, Qian Chen, Fangzhou Jiao, Chunxia Shi, Maohua Pei in Cell Death & Disease (2021)

  3. No Access

    Article

    AGK2 Alleviates Lipopolysaccharide Induced Neuroinflammation through Regulation of Mitogen-Activated Protein Kinase Phosphatase-1

    Neuroinflammation is associated with the progression of multiple neurological diseases. Many studies show that SIRT2 involves in multiple inflammatory processes. While, the mechanisms remain unclear. The purpo...

    Fangzhou Jiao, Yao Wang, Wenbin Zhang, Haiyue Zhang in Journal of Neuroimmune Pharmacology (2020)