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Open AccessThe factors of job crafting in emergency nurses: regression models versus qualitative comparative analysis
Job crafting is defined as a series of proactive behaviors exhibited by employees in order to balance work resources and needs, which has a significant positive impact on the nurses. It is necessary to find th...
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Article
Open AccessBioinspired soft robots for deep-sea exploration
The deep ocean, Earth’s untouched expanse, presents immense challenges for exploration due to its extreme pressure, temperature, and darkness. Unlike traditional marine robots that require specialized metallic...
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Article
Open AccessComparison of efficacy between laparoscopic pectopexy and laparoscopic high uterosacral ligament suspension in the treatment of apical prolapse-short term results
To compare the clinical efficacy of laparoscopic pectopexy and laparoscopic high uterosacral ligament suspension in women suffering from apical prolapse. The clinical data of 170 patients with apical prolapse ...
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Article
Open AccessEffect of P53 nuclear localization mediated by G3BP1 on ferroptosis in acute liver failure
This study investigated whether G3BP1 could regulate ferroptosis in hepatocytes during ALF by affecting the entry of P53 into the nucleus. Promoting G3BP1 expression could inhibit P53 entry by binding to the n...
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Article
The Synergism between Methanogens and Methanotrophs and the Nature of their Contributions to the Seasonal Variation of Methane Fluxes in a Wetland: The Case of Dajiuhu Subalpine Peatland
Wetland ecosystems are the most important natural methane (CH4) sources, whose fluxes periodically fluctuate. Methanogens (methane producers) and methanotrophs (methane consumers) are considered key factors affec...
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Open AccessAuthor Correction: FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease
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Article
Open AccessFusobacterium nucleatum promotes the development of acute liver failure by inhibiting the NAD+ salvage metabolic pathway
Acute liver failure (ALF) patients are often accompanied by severe energy metabolism abnormalities and intestinal microecological imbalance. The intestinal mucosal barrier is severely damaged. Intestinal endot...
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Article
Open AccessHistone deacetylase 2 regulates ULK1 mediated pyroptosis during acute liver failure by the K68 acetylation site
Pyroptosis is a new necrosis pattern of hepatocyte during liver inflammation in acute liver failure (ALF). Histone deacetylase 2 (HDAC2) is associated with several pathological conditions in the liver system. ...
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Article
Open AccessBetaine inhibits Toll-like receptor 4 responses and restores intestinal microbiota in acute liver failure mice
Previous research has revealed that the gut microbiome has a marked impact on acute liver failure (ALF). Here, we evaluated the impact of betaine on the gut microbiota composition in an ALF animal model. The p...
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Article
Open AccessSENP7 knockdown inhibited pyroptosis and NF-κB/NLRP3 inflammasome pathway activation in Raw 264.7 cells
Pyroptosis is a kind of necrotic and inflammatory programmed cell death induced by inflammatory caspases. SENP7 is a SUMO-specific protease, which mainly acts on deconjugation of SUMOs from substrate proteins....
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Article
Clinical Challenges in an Outbreak of COVID-19 in Wuhan, China: Concerns from Frontiers
In December 2019, outbreaks of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected pneumonia patients were discovered in Wuhan City, Hubei Province, China. With the spread of the epidemic, ne...
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AGK2 Alleviates Lipopolysaccharide Induced Neuroinflammation through Regulation of Mitogen-Activated Protein Kinase Phosphatase-1
Neuroinflammation is associated with the progression of multiple neurological diseases. Many studies show that SIRT2 involves in multiple inflammatory processes. While, the mechanisms remain unclear. The purpo...
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Open AccessFAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease
Alzheimer’s disease (AD) is characterized by amyloid plaques and progressive cerebral atrophy. Here, we report FAM222A as a putative brain atrophy susceptibility gene. Our cross-phenotype association analysis of ...
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Article
Low Remanent Polarization for High Energy Density by Poly(vinylidene fluoride-co-chlorotrifluoroethylene)/Silicon Dioxide Nanocomposites
Nowadays, dielectric materials with high energy storage density play a vital role in the energy storage capacitors. To increase the storage density, 0–3 composite films based on poly(vinylidene fluoride-co-chloro...
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Article
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity
ALS-associated mutations in TDP-43 enhance its localization to mitochondria, and the inhibition of mitochondrial targeting reduces neuronal toxicity and alleviates motor phenotypes induced by TDP-43 expression...
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Article
Open AccessSilicon-based micro direct methanol fuel cell with an N-inputs-N-outputs anode flow pattern
A micro direct methanol fuel cell (μDMFC) is suitable for use in notebook computers, mobile phones, and other digital products. To resolve the poor mass-transport efficiency problem in the anode flow channel, ...
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Article
Open AccessEffects of S-adenosylmethionine on liver methionine metabolism and steatosis with ethanol-induced liver injury in rats
Hyperhomocysteinemia is implicated in the pathogenesis of various liver diseases. In this study, the effects of S-adenosylmethionine (SAM) on hyperhomocysteinemia and steatosis with ethanol-induced liver injury i...
