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Article
Open AccessmeQTL map** in the GENOA study reveals genetic determinants of DNA methylation in African Americans
Identifying genetic variants that are associated with variation in DNA methylation, an analysis commonly referred to as methylation quantitative trait locus (meQTL) map**, is an important first step towards ...
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Article
Open AccessSRTsim: spatial pattern preserving simulations for spatially resolved transcriptomics
Spatially resolved transcriptomics (SRT)-specific computational methods are often developed, tested, validated, and evaluated in silico using simulated data. Unfortunately, existing simulated SRT data are ofte...
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Article
Open AccessSpatially aware dimension reduction for spatial transcriptomics
Spatial transcriptomics are a collection of genomic technologies that have enabled transcriptomic profiling on tissues with spatial localization information. Analyzing spatial transcriptomic data is computatio...
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Article
Open AccessIdentification of functionally important miRNA targeted genes associated with child obesity trait in genome-wide association studies
Genome-wide association studies (GWAS) have uncovered thousands of genetic variants that are associated with complex human traits and diseases. miRNAs are single-stranded non-coding RNAs. In particular, geneti...
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Article
Open AccessPinpointing miRNA and genes enrichment over trait-relevant tissue network in Genome-Wide Association Studies
Understanding gene regulation is important but difficult. Elucidating tissue-specific gene regulation mechanism is even more challenging and requires gene co-expression network assembled from protein–protein i...
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Article
Open AccessEpigenetic loci for blood pressure are associated with hypertensive target organ damage in older African Americans from the genetic epidemiology network of Arteriopathy (GENOA) study
Hypertension is a major modifiable risk factor for arteriosclerosis that can lead to target organ damage (TOD) of heart, kidneys, and peripheral arteries. A recent epigenome-wide association study for blood pr...
