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Open AccessDigitalisierung in der Lehre der Neurologie und Psychiatrie
Digitalisierung in der Medizin gehört zur Zukunft der akademischen Medizin. Diesem Fakt wird auch in der Lehre Rechnung getragen. Da Lehre immer forschungsgeleitet gestaltet ist, sind auch die lerntheoretische...
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Open AccessFunctional connectivity signatures of major depressive disorder: machine learning analysis of two multicenter neuroimaging studies
The promise of machine learning has fueled the hope for develo** diagnostic tools for psychiatry. Initial studies showed high accuracy for the identification of major depressive disorder (MDD) with resting-s...
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Open AccessAltered resting-state functional connectome in major depressive disorder: a mega-analysis from the PsyMRI consortium
Major depressive disorder (MDD) is associated with abnormal neural circuitry. It can be measured by assessing functional connectivity (FC) at resting-state functional MRI, that may help identifying neural mark...
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Open AccessOn the relationship of first-episode psychosis to the amphetamine-sensitized state: a dopamine D2/3 receptor agonist radioligand study
Schizophrenia is characterized by increased behavioral and neurochemical responses to dopamine-releasing drugs. This prompted the hypothesis of psychosis as a state of “endogenous” sensitization of the dopamin...
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Open AccessPrefrontal networks dynamically related to recovery from major depressive disorder: a longitudinal pharmacological fMRI study
Due to lacking predictors of depression recovery, successful treatment of major depressive disorder (MDD) is frequently only achieved after therapeutic optimization leading to a prolonged suffering of patients...
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Article
Open AccessMidday and nadir salivary cortisol appear superior to cortisol awakening response in burnout assessment and monitoring
Burnout and work-related stress symptoms of anxiety disorder and depression cause prolonged work absenteeism and early retirement. Hence, reliable identification of patients under risk and monitoring of treatm...
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Article
Open AccessOppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults
Prefrontal dopamine levels are relatively increased in adolescence compared to adulthood. Genetic variation of COMT (COMT Val158Met) results in lower enzymatic activity and higher dopamine availability in Met car...
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Article
Open AccessfMRI measurements of amygdala activation are confounded by stimulus correlated signal fluctuation in nearby veins draining distant brain regions
Imaging the amygdala with functional MRI is confounded by multiple averse factors, notably signal dropouts due to magnetic inhomogeneity and low signal-to-noise ratio, making it difficult to obtain consistent ...
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Reference Work Entry In depth
Recurrent Brief Depressive Disorder
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Living Reference Work Entry In depth
Recurrent Brief Depressive Disorder
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Article
A highly parallelized framework for computationally intensive MR data analysis
The goal of this study was to develop a comprehensive magnetic resonance (MR) data analysis framework for handling very large datasets with user-friendly tools for parallelization and to provide an example imp...
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Article
Is there a personalized medicine for mood disorders?
Major Depressive Disorder (MDD) and antidepressant therapy response are largely based on behavioral criteria, which are known to correlate at best modestly with biological measures. Therefore, it is not surpri...
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Reference Work Entry In depth
Recurrent Brief Depressive Disorder
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Article
5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression
Carriers of the short allele of a functional 5′ promoter polymorphism of the serotonin transporter gene have increased anxiety-related temperamental traits, increased amygdala reactivity and elevated risk of d...
