From Malignant Transformation to Metastasis
Ion Transport in Tumor Biology
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Open AccessSK3 Channel Overexpression in Mice Causes Hippocampal Shrinkage Associated with Cognitive Impairments
The dysfunction of the small-conductance calcium-activated K+ channel SK3 has been described as one of the factors responsible for the progress of psychoneurological diseases, but the molecular basis of this is l...
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Article
Ion channels, transporters and cancer (“INCA2015”): an international meeting in honor of Prof. Dr. Walter Stühmer
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Open AccessIn vivo imaging of tumour xenografts with an antibody targeting the potassium channel Kv10.1
The Kv10.1 (Eag1) voltage-gated potassium channel represents a promising molecular target for novel cancer therapies or diagnostic purposes. Physiologically, it is only expressed in the brain, but it was found ov...
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Open AccessGuiding TRAIL to cancer cells through Kv10.1 potassium channel overcomes resistance to doxorubicin
Resisting cell death is one of the hallmarks of cancer, and represents a common problem resulting in ineffective cancer therapy. To overcome resistance to apoptosis, we designed an antibody-based therapy strat...
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Kv10.1 K+ channel: from physiology to cancer
K+ ions play a major role in many cellular processes. The deregulation of K+ signaling is associated with a variety of diseases including cancer. Ether-à-go-go-1 (Eag1, Kv10.1, KCNH1) is a member of the voltage-a...
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Open AccessVoltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains
Voltage-gated channels open paths for ion permeation upon changes in membrane potential, but how voltage changes are coupled to gating is not entirely understood. Two modules can be recognized in voltage-gated...
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The roles of K+ channels in cancer
Ion transport molecules are involved in many physiological and pathological processes.
Among ion transporte...
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Frequent aberrant expression of the human ether à go-go (hEAG1) potassium channel in head and neck cancer: pathobiological mechanisms and clinical implications
Compelling evidence indicates that the human ether-à-go-go voltage-gated potassium channels (hEAG1) may represent new valuable membrane therapeutic targets and diagnostic/prognostic biomarkers in various cancers....
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Article
Open AccessNucleofection induces non-specific changes in the metabolic activity of transfected cells
Transfection has become an everyday technique widely used for functional studies in living cells. The choice of the particular transfection method is usually determined by its efficiency and toxicity, and poss...
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Open AccessTumor cell-selective apoptosis induction through targeting of KV10.1 via bifunctional TRAIL antibody
The search for strategies to target ion channels for therapeutic applications has become of increasing interest. Especially, the potassium channel KV10.1 (Ether-á-go-go) is attractive as target since this surface...
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Open AccessThe potassium channel Ether à go-go is a novel prognostic factor with functional relevance in acute myeloid leukemia
The voltage-gated potassium channel hEag1 (KV10.1) has been related to cancer biology. The physiological expression of the human channel is restricted to the brain but it is frequently and abundantly expressed in...
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Voltage-gated potassium channels as therapeutic targets
Voltage-gated K+ (KV) channels regulate various physiological and pathophysiological processes and offer tremendous opportunities for the development of new dr...
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Article
Open AccessThe voltage dependence of hEag currents is not determined solely by membrane-spanning domains
The ether-à-go-go potassium channels hEag1 and hEag2 are highly homologous. Even though both possess identical voltage-sensing domain S4, the channels act differently in response to voltage. Therefore we asked...
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Article
Open AccessEther à go-go potassium channel expression in soft tissue sarcoma patients
The expression of the human Eag1 potassium channel (Kv10.1) is normally restricted to the adult brain, but it has been detected in both tumour cell lines and primary tumours. Our purpose was to determine the f...
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Open AccessOverexpression of Eag1 potassium channels in clinical tumours
Certain types of potassium channels (known as Eag1, KCNH1, Kv10.1) are associated with the production of tumours in patients and in animals. We have now studied the expression pattern of the Eag1 channel in a ...
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Cytoskeletal interactions determine the electrophysiological properties of human EAG potassium channels
The electrophysiological properties of ether à go-go (EAG) potassium channels are modified during the cell cycle when they are expressed in heterologous systems. In Chinese hamster ovary (CHO) mammalian somatic ...
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Demonstration of an inwardly rectifying K+ current component modulated by thyrotropin-releasing hormone and caffeine in GH3 rat anterior pituitary cells
Reduction of an inwardly rectifying K+ current by thyrotropin-releasing hormone (TRH) and caffeine has been considered to be an important determinant of electrical activity increases in GH3 rat anterior pituitar...
