24 Result(s)
-
Article
Hyposmia correlates with axial signs and gait disorder in Parkinson’s disease: an Italian Olfactory Identification Test study
Olfactory dysfunction is a non-motor symptom and an important biomarker of Parkinson’s disease (PD) because of its high prevalence (> 90%). Whether hyposmia correlates with motor symptoms is unclear. In the pr...
-
Article
Open AccessRedefinition of dementia care in Italy in the era of amyloid-lowering agents for the treatment of Alzheimer’s disease: an expert opinion and practical guideline
No disease-modifying therapies are currently available for Alzheimer’s disease (AD) in Europe. Current evidence from clinical trials testing anti-beta amyloid (Aβ) monoclonal antibodies (mAbs) in patients with...
-
Article
Open AccessCerebrospinal fluid levels of proenkephalin and prodynorphin are differentially altered in Huntington’s and Parkinson’s disease
Proenkephalin (PENK) and prodynorphin (PDYN) are peptides mainly produced by the striatal medium spiny projection neurons (MSNs) under dopaminergic signaling. Therefore, they may represent candidate biomarkers...
-
Article
Open AccessAccuracy of the clinical diagnosis of dementia with Lewy bodies (DLB) among the Italian Dementia Centers: a study by the Italian DLB study group (DLB-SINdem)
Dementia with Lewy bodies (DLB) may represent a diagnostic challenge, since its clinical picture overlaps with other dementia. Two toolkits have been developed to aid the clinician to diagnose DLB: the Lewy Bo...
-
Article
The no evidence of disease activity (NEDA) concept in MS: impact of spinal cord MRI
Measures to define treatment response, such as no evidence of disease activity (NEDA), are routinely used in multiple sclerosis (MS) clinical practice. Although spinal cord involvement is a frequent feature of...
-
Article
Open AccessPEG-J replacement for duodenal levodopa infusion in Parkinson’s disease patients: a retrospective study
Reducing percutaneous endoscopic gastrostomies with jejunal extension tubes (PEG-J) related complications is vital to the long-term preservation of duodenal levodopa infusion (DLI) in advanced Parkinson’s dise...
-
Article
Small-expanded allele spinocerebellar ataxia 17: imaging and phenotypic variability
Spinocerebellar ataxia 17 (SCA17) is a rare genetic cause of adult-onset ataxia caused by an abnormal expansion of the CAG/CAA sequence in the TATA-box Binding Protein (TBP) gene. A number of repeats higher than ...
-
Article
Amyloid-β: a potential link between epilepsy and cognitive decline
People with epilepsy — in particular, late-onset epilepsy of unknown aetiology — have an elevated risk of dementia, and seizures have been detected in the early stages of Alzheimer disease (AD), supporting the...
-
Article
Changes of olfactory tract in Parkinson’s disease: a DTI tractography study
Impaired olfactory function is one of the main features of Parkinson’s disease. However, how peripheral olfactory structures are involved remains unclear. Using diffusion tensor imaging fiber tracking, we inve...
-
Article
The Italian version of Cognitive Function Instrument (CFI) for tracking changes in healthy elderly: results at 1-year follow-up
Cognitive Function Instrument (CFI) is a questionnaire aimed at detecting very early changes in cognitive and functional abilities and useful for monitoring cognitive decline in individuals without clinical im...
-
Article
Cerebrospinal fluid neurofilament light chain tracks cognitive impairment in multiple sclerosis
Cognitive impairment (CI) is a disabling symptom of multiple sclerosis (MS). Axonal damage disrupts neural circuits and may play a role in determining CI, but its detection and monitoring are not routinely per...
-
Article
Open AccessNovel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer’s disease
Tau is an axonal microtubule-binding protein. Tau pathology in brain and increased tau concentration in the cerebrospinal fluid (CSF) are hallmarks of Alzheimer’s disease (AD). Most of tau in CSF is present as...
-
Article
CSF Biomarkers for Early Diagnosis of Synucleinopathies: Focus on Idiopathic RBD
Idiopathic REM sleep behavior disorder (iRBD) is one of the most significant prodromal manifestations of synucleinopathies. Different predictive biomarkers for iRBD conversion have been investigated, but scarc...
-
Article
The Italian version of cognitive function instrument (CFI): reliability and validity in a cohort of healthy elderly
The Alzheimer’s disease Cooperative Study (ADCS)-Cognitive Function Instrument (CFI) is a 14-item questionnaire administered to the subject and the referent, aimed at detecting early changes in cognitive and f...
-
Article
Open Access19th biennial IPEG Meeting
-
Article
Cerebrospinal fluid biomarkers in trials for Alzheimer and Parkinson diseases
Cerebrospinal fluid (CSF) biomarkers can track relevant pathophysiological changes that occur in the brains of patients with Alzheimer disease (AD)
... -
Article
Cerebrospinal fluid biomarkers in Parkinson disease
Parkinson disease (PD) begins with a long preclinical phase, which represents both a diagnostic challenge and a potential therapeutic opportunity for early intervention. Parnetti and colleagues discuss growing...
-
Article
Position paper of the Italian Society for the study of Dementias (Sindem) on the proposal of a new Lexicon on Alzheimer disease
A panel of Italian neurologists of the Italian Society for the study of Dementias (SINDEM) discussed the recently proposed new lexicon for Alzheimer disease (AD) and the related diagnostic criteria for the dif...
-
Article
Selection of thrombogenetic antiphospholipid antibodies in cerebrovascular disease patients
Background and Purpose: The association between anticardiolipin antibodies (aCL) and thrombosis is well recognized, but its role as an independent risk factor for stroke is not. The study's aim was to investigat...
-
Article
Headache and ischemic stroke
Migraine is a common neurological condition affecting yearly 1%–10% of all men and 3%–20% of all women. Focal neurological symptoms (auras), most commonly visual and sensory, occur in 4% of migraine attacks. M...
