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Article
Open AccessPhase transitions in TGFT: a Landau-Ginzburg analysis of Lorentzian quantum geometric models
In the tensorial group field theory (TGFT) approach to quantum gravity, the basic quanta of the theory correspond to discrete building blocks of geometry. It is expected that their collective dynamics gives ri...
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Article
Open AccessPhase transitions in tensorial group field theories: Landau-Ginzburg analysis of models with both local and non-local degrees of freedom
In the tensorial group field theory approach to quantum gravity, the theory is based on discrete building blocks and continuum spacetime is expected to emerge from their collective dynamics, possibly at critic...
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Article
Open AccessQSPcc reduces bottlenecks in computational model simulations
Mathematical models have grown in size and complexity becoming often computationally intractable. In sensitivity analysis and optimization phases, critical for tuning, validation and qualification, these model...
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Article
Open AccessEffective relational cosmological dynamics from quantum gravity
We discuss the relational strategy to solve the problem of time in quantum gravity and different ways in which it could be implemented, pointing out in particular the fundamentally new dimension that the probl...
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Article
Nutritional and nutraceutical properties of raw and traditionally obtained flour from chestnut fruit grown in Tuscany
The study of local chestnut and traditional techniques related to their use and consumption are considered of primary importance to promote their nutritional/nutraceutical values. Fruit of four local chestnut ...
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Article
Open AccessAdvancing brain barriers RNA sequencing: guidelines from experimental design to publication
RNA sequencing (RNA-Seq) in its varied forms has become an indispensable tool for analyzing differential gene expression and thus characterization of specific tissues. Aiming to understand the brain barriers g...
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Article
Open AccessA QSP model of prostate cancer immunotherapy to identify effective combination therapies
Immunotherapy, by enhancing the endogenous anti-tumor immune responses, is showing promising results for the treatment of numerous cancers refractory to conventional therapies. However, its effectiveness for a...
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Article
Open AccessTissue oxygen saturation changes and postoperative complications in cardiac surgery: a prospective observational study
Cardiac surgery with extracorporeal circulation (ECC) can induce microvascular dysfunction and tissue hypoperfusion. We hypothesized that the alterations in near-infrared spectroscopy (NIRS)-derived parameters...
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Article
Experimental study: comparison of conventional and low-frequency vibration-assisted drilling (LF-VAD) of CFRP/aluminium stacks
The increasing substitution of metallic structural components by carbon fibre reinforced polymers (CFRP) in aerospace applications results in a growing need for drilling metal and CFRP in one operation, the so...
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Article
Open AccessStereotactic radiosurgery combined with nivolumab or Ipilimumab for patients with melanoma brain metastases: evaluation of brain control and toxicity
To investigate the efficacy and safety of concurrent stereotactic radiosurgery (SRS) and ipilimumab or nivolumab in patients with untreated melanoma brain metastases.
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Article
Open AccessThe 5-formyltetrahydrofolate futile cycle reduces pathway stochasticity in an extended hybrid-stochastic model of folate-mediated one-carbon metabolism
In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor o...
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Article
Cross-species evidence from human and rat brain transcriptome for growth factor signaling pathway dysregulation in major depression
An enhanced understanding of the pathophysiology of depression would facilitate the discovery of new efficacious medications. To this end, we examined hippocampal transcriptional changes in rat models of disea...
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Article
Open AccessAbstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers
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Article
Diegetic user interfaces for virtual environments with HMDs: a user experience study with oculus rift
Research efforts, in the area of virtual reality, have mostly concentrated on the design and implementation of devices supporting user presence in immersive environments. Much can be done, however, to further ...
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Article
Open AccessA hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesis
Folate-mediated one-carbon metabolism (FOCM) is an interconnected network of metabolic pathways, including those required for the de novo synthesis of dTMP and purine nucleotides and for remethylation of homocyst...
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Article
Open AccessTreating triple negative breast cancer cells with erlotinib plus a select antioxidant overcomes drug resistance by targeting cancer cell heterogeneity
Among breast cancer patients, those diagnosed with the triple-negative breast cancer (TNBC) subtype have the worst prog-nosis. TNBC does not express estrogen receptor-alpha, progesterone receptor, or the HER2 ...
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Chapter
Introduction
A cell is the basic unit of all known living organisms. Cells with specific roles are then organized to form higher levels such as tissues and organs. The cell is essentially a dynamical system whose behaviors...
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Chapter
Implementations of the Stochastic Simulation Algorithm
The stochastic simulation algorithm (SSA) is a stochastic, discrete event simulation strategy where a reaction is randomly selected to update the system state. It has the nice property of producing an exact re...
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Chapter
Hybrid Simulation Algorithms
In this chapter we will introduce hybrid simulation strategies as a combination of previously introduced simulation algorithms. Hybrid simulation combines the advantages of complementary simulation approaches:...
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Chapter
Stochastic Simulation of Biochemical Reaction Systems
This chapter presents the foundational theory of the stochastic chemical kinetics for modeling biochemical reaction networks, of which the discreteness in population of species and the randomness of reactions are...
