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Article
Open AccessStudy protocol for a randomised controlled trial to investigate the effectiveness of thoracic epidural and paravertebral blockade in reducing chronic post-thoracotomy pain: 2 (TOPIC 2)
Thoracotomy is considered one of the most painful surgical procedures and can cause debilitating chronic post-surgical pain lasting months or years postoperatively. Aggressive management of acute pain resultin...
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Article
Open AccessIntravaginal lactic acid gel versus oral metronidazole for treating women with recurrent bacterial vaginosis: the VITA randomised controlled trial
Bacterial vaginosis is a common and distressing condition for women. Short-term antibiotic treatment is usually clinically effective, but recurrence is common. We assessed the effectiveness of intravaginal lac...
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Article
Open AccessProtocol for a parallel group, two-arm, superiority cluster randomised trial to evaluate a community-level complementary-food safety and hygiene and nutrition intervention in Mali: the MaaCiwara study (version 1.3; 10 November 2022)
Diarrhoeal disease remains a significant cause of morbidity and mortality among the under-fives in many low- and middle-income countries. Changes to food safety practices and feeding methods around the weaning...
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Article
Open AccessThe DEVA trial: protocol for a randomised controlled trial of dequalinium chloride versus usual care antibiotics for the treatment of bacterial vaginosis
Bacterial vaginosis (BV) is the most common cause of vaginal discharge in women of reproductive age, and it is estimated that up to a third of women will experience it at some point in their lives. BV produces...
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Article
Open AccessSupporting pregnant women not ready to quit smoking: an economic evaluation
Some pregnant women are not ready or do not want to quit smoking completely, and currently there is no support provided for these women in the UK. Offering help to reduce smoking could reduce the health risks ...
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Article
Open AccessHealth outcomes of smoking during pregnancy and the postpartum period: an umbrella review
Smoking during pregnancy (SDP) and the postpartum period has serious health outcomes for the mother and infant. Although some systematic reviews have shown the impact of maternal SDP on particular conditions, ...
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Article
Open AccessDevelopment of an electronic patient-reported outcome measure (ePROM) system to aid the management of patients with advanced chronic kidney disease
Effective management of patients with chronic kidney disease (CKD) relies on timely detection of clinical deterioration towards end stage kidney failure. We aimed to design an electronic Patient-Reported Outco...
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Article
Open AccessMetronidazole versus lactic acid for treating bacterial vaginosis (VITA): protocol for a randomised controlled trial to assess the clinical and cost effectiveness of topical lactic acid gel for treating second and subsequent episodes of bacterial vaginosis
Bacterial vaginosis (BV) affects 30–50% of women at some time in their lives and is an embarrassing and distressing condition which can be associated with potentially serious comorbidities. Current antibiotic ...
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Article
Open AccessHealth outcomes of maternal smoking during pregnancy and postpartum period for the mother and infant: protocol for an umbrella review
Internationally, tobacco smoking is a leading cause of mortality, morbidity and health inequality. In England, despite increasing awareness about importance of public health interventions to reduce smoking, ab...
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Article
Open AccessA cluster-randomised feasibility trial of a children’s weight management programme: the Child weigHt mANaGement for Ethnically diverse communities (CHANGE) study
Community-based programmes for children with excess weight are widely available, but few have been developed to meet the needs of culturally diverse populations. We adapted an existing children’s weight manage...
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Article
Correction: Corrigendum: Climate-smart agriculture for food security
Nature Clim. Change 4, 1068–1072 (2014); published online 26 November 2014; corrected after print 13 March 2015 In the version of this Perspective originally published, the list of authors and affiliations sho...
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Article
Open AccessNOURISH, Nutritional OUtcomes from a Randomised Investigation of Intradialytic oral nutritional Supplements in patients receiving Haemodialysis: a pilot randomised controlled trial
The study was done to assess the feasibility of conducting a trial evaluating the use of an intradialytic oral nutritional supplement (ONS) on nutritional status.
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Article
Climate-smart agriculture for food security
Climate-smart agriculture (CSA) is an approach to the development of agricultural systems intended to help support food security under climate change. This Perspective outlines a set of CSA actions needed from...
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Article
Open AccessNutritional outcomes from a randomised investigation of intradialytic oral nutritional supplements in patients receiving haemodialysis, (NOURISH): a protocol for a pilot randomised controlled trial
Haemodialysis is a form of renal replacement therapy but is a catabolic process that not only filters toxins but is also known to lead to amino acid losses. Patients with chronic kidney disease often have a po...
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Article
Factors affecting adoption of hedgerows and other biodiversity-enhancing features on farms in California, USA
Although hedgerows, windbreaks, and other biodiversity-enhancing farm edge features offer the potential for ecosystem benefits without occupying much crop space, relatively few farms in California, USA include...
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Article
Calibrating the zoom — a test of Zitt’s hypothesis
Bibliometric indicators are widely used to compare performance between units operating in different fields of science.
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Childhood and Youth
Histories of youth and sexuality have overwhelmingly examined processes of categorization and regulation by adults rather than the experiences of young people themselves. This is to a large extent a function o...
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Simulated Water Budgets for an Annual Grassland Site in the Sierra Foothills
In California’s annual grassland and oak woodland, rainfall is high during winter but almost nonexistent during the hot summers (Major 1977). As a consequence, the season with warm temperatures and the season ...
