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Article
Open AccessDynamics of replication origin over-activation
Safeguards against excess DNA replication are often dysregulated in cancer, and driving cancer cells towards over-replication is a promising therapeutic strategy. We determined DNA synthesis patterns in cancer...
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Article
Open AccessCurrently favored sampling practices for tumor sequencing can produce optimal results in the clinical setting
Tumor heterogeneity is a consequence of clonal evolution, resulting in a fractal-like architecture with spatially separated main clones, sub-clones and single-cells. As sequencing an entire tumor is not feasib...
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Article
Open AccessBAMscale: quantification of next-generation sequencing peaks and generation of scaled coverage tracks
Next-generation sequencing allows genome-wide analysis of changes in chromatin states and gene expression. Data analysis of these increasingly used methods either requires multiple analysis steps, or extensive...
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Article
Open AccessThe RepID–CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation
The spindle assembly checkpoint (SAC) prevents premature chromosome segregation by inactivating the anaphase promoting complex/cyclosome (APC/C) until all chromosomes are properly attached to mitotic spindles....
