5 Result(s)

Article

Nicotinamide Riboside, an NAD + Precursor, Protects Against Cardiac Mitochondrial Dysfunction in Fetal Guinea Pigs Exposed to Gestational Hypoxia

Gestational hypoxia inhibits mitochondrial function in the fetal heart and placenta contributing to fetal growth restriction and organ dysfunction. NAD + deficiency may contribute to a metabolic deficit by inh...

Loren P. Thompson, Hong Song, Jamie Hartnett in Reproductive Sciences (2024)

Article

Effects of Gestational Hypoxia on PGC1α and Mitochondrial Acetylation in Fetal Guinea Pig Hearts

Chronic intrauterine hypoxia is a significant pregnancy complication impacting fetal heart growth, metabolism, and mitochondrial function, contributing to cardiovascular programming of the offspring. PGC1α (pe...

Hong Song, Loren P. Thompson in Reproductive Sciences (2023)

Article

Chronic hypoxia increases peroxynitrite, MMP9 expression, and collagen accumulation in fetal guinea pig hearts

Chronic hypoxia increases the expression of inducible nitric oxide synthase (iNOS) mRNA and protein levels in fetal guinea pig heart ventricles. Excessive generation of nitric oxide (NO) can induce nitrosative...

LaShauna C. Evans, Hongshan Liu, Gerard A. Pinkas, Loren P. Thompson in Pediatric Research (2012)

Article

Aspen Perinatal Biology Conference: August 28–31, 2010

Loren P Thompson, Michele Brochu, Joel S Caton, Jacob E Friedman in Pediatric Research (2010)

Article

Acetylcholine Relaxation of Renal Artery and Nitric Oxide Synthase Activity of Renal Cortex Increase with Fetal and Postnatal Age

Endothelium-derived nitric oxide (NO) regulates hemodynamics in the fetal kidney and modulates renal perfusion during postnatal maturation. We hypothesize that NO release by renal arteries increases with fetal...

Loren P Thompson, Carl P Weiner in Pediatric Research (1996)